Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults

Robert T. Mankowski, Stephen D. Anton, Robert Axtell, Shyh Huei Chen, Roger A. Fielding, Nancy W. Glynn, Fang Chi Hsu, Abby C. King, Andrew S. Layne, Christiaan Leeuwenburgh, Todd M. Manini, Anthony P. Marsh, Marco Pahor, Catrine Tudor-Locke, David E. Conroy, Thomas W. Buford

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: To examine associations between objectively measured physical activity (PA) and incidence of major mobility disability (MMD) and persistent MMD (PMMD) in older adults in the Lifestyle Interventions and Independence for Elders (LIFE) Study. Design: Prospective cohort of individuals aged 65 and older undergoing structured PA intervention or health education. Setting: The LIFE Study was a multicenter (eight sites) randomized controlled trial designed to compare the efficacy of a long-term structured PA intervention with that of a health education (HE) program in reducing the incidence of MMD in mobility-limited older adults. Participants: LIFE Study participants (n = 1,590) had a mean age±standard deviation of 78.9 ± 5.2, low levels of PA, and measured mobility-relevant functional impairment at baseline. Measurements: Activity data were collected using hip-worn 7-day accelerometers at baseline and 6, 12, and 24 months after randomization to test for associations with incident MMD and PMMD (≥2 consecutive instances of MMD). Results: At baseline, every 30 minutes spent being sedentary (<100 accelerometry counts per minute) was associated with higher rate of subsequent MMD (10%) and PMMD (11%) events. Every 500 steps taken was associated with lower rate of MMD (15%) and PMMD (18%). Similar associations were observed when fitting accelerometry-based PA as a time-dependent variable. Conclusion: Accelerometry-based PA levels were strongly associated with MMD and PMMD events in older adults with limited mobility. These results support the importance of daily PA and lower amounts of sedentary time levels in this population and suggest that accelerometry may be a useful tool for assessing risk of mobility disability.

Original languageEnglish (US)
Pages (from-to)2251-2256
Number of pages6
JournalJournal of the American Geriatrics Society
Volume65
Issue number10
DOIs
StatePublished - Oct 1 2017

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Accelerometry
Life Style
Equipment and Supplies
Health Education
Incidence
Random Allocation
Hip
Randomized Controlled Trials
Population

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Mankowski, R. T., Anton, S. D., Axtell, R., Chen, S. H., Fielding, R. A., Glynn, N. W., ... Buford, T. W. (2017). Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults. Journal of the American Geriatrics Society, 65(10), 2251-2256. https://doi.org/10.1111/jgs.15037
Mankowski, Robert T. ; Anton, Stephen D. ; Axtell, Robert ; Chen, Shyh Huei ; Fielding, Roger A. ; Glynn, Nancy W. ; Hsu, Fang Chi ; King, Abby C. ; Layne, Andrew S. ; Leeuwenburgh, Christiaan ; Manini, Todd M. ; Marsh, Anthony P. ; Pahor, Marco ; Tudor-Locke, Catrine ; Conroy, David E. ; Buford, Thomas W. / Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults. In: Journal of the American Geriatrics Society. 2017 ; Vol. 65, No. 10. pp. 2251-2256.
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title = "Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults",
abstract = "Objectives: To examine associations between objectively measured physical activity (PA) and incidence of major mobility disability (MMD) and persistent MMD (PMMD) in older adults in the Lifestyle Interventions and Independence for Elders (LIFE) Study. Design: Prospective cohort of individuals aged 65 and older undergoing structured PA intervention or health education. Setting: The LIFE Study was a multicenter (eight sites) randomized controlled trial designed to compare the efficacy of a long-term structured PA intervention with that of a health education (HE) program in reducing the incidence of MMD in mobility-limited older adults. Participants: LIFE Study participants (n = 1,590) had a mean age±standard deviation of 78.9 ± 5.2, low levels of PA, and measured mobility-relevant functional impairment at baseline. Measurements: Activity data were collected using hip-worn 7-day accelerometers at baseline and 6, 12, and 24 months after randomization to test for associations with incident MMD and PMMD (≥2 consecutive instances of MMD). Results: At baseline, every 30 minutes spent being sedentary (<100 accelerometry counts per minute) was associated with higher rate of subsequent MMD (10{\%}) and PMMD (11{\%}) events. Every 500 steps taken was associated with lower rate of MMD (15{\%}) and PMMD (18{\%}). Similar associations were observed when fitting accelerometry-based PA as a time-dependent variable. Conclusion: Accelerometry-based PA levels were strongly associated with MMD and PMMD events in older adults with limited mobility. These results support the importance of daily PA and lower amounts of sedentary time levels in this population and suggest that accelerometry may be a useful tool for assessing risk of mobility disability.",
author = "Mankowski, {Robert T.} and Anton, {Stephen D.} and Robert Axtell and Chen, {Shyh Huei} and Fielding, {Roger A.} and Glynn, {Nancy W.} and Hsu, {Fang Chi} and King, {Abby C.} and Layne, {Andrew S.} and Christiaan Leeuwenburgh and Manini, {Todd M.} and Marsh, {Anthony P.} and Marco Pahor and Catrine Tudor-Locke and Conroy, {David E.} and Buford, {Thomas W.}",
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Mankowski, RT, Anton, SD, Axtell, R, Chen, SH, Fielding, RA, Glynn, NW, Hsu, FC, King, AC, Layne, AS, Leeuwenburgh, C, Manini, TM, Marsh, AP, Pahor, M, Tudor-Locke, C, Conroy, DE & Buford, TW 2017, 'Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults', Journal of the American Geriatrics Society, vol. 65, no. 10, pp. 2251-2256. https://doi.org/10.1111/jgs.15037

Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults. / Mankowski, Robert T.; Anton, Stephen D.; Axtell, Robert; Chen, Shyh Huei; Fielding, Roger A.; Glynn, Nancy W.; Hsu, Fang Chi; King, Abby C.; Layne, Andrew S.; Leeuwenburgh, Christiaan; Manini, Todd M.; Marsh, Anthony P.; Pahor, Marco; Tudor-Locke, Catrine; Conroy, David E.; Buford, Thomas W.

In: Journal of the American Geriatrics Society, Vol. 65, No. 10, 01.10.2017, p. 2251-2256.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults

AU - Mankowski, Robert T.

AU - Anton, Stephen D.

AU - Axtell, Robert

AU - Chen, Shyh Huei

AU - Fielding, Roger A.

AU - Glynn, Nancy W.

AU - Hsu, Fang Chi

AU - King, Abby C.

AU - Layne, Andrew S.

AU - Leeuwenburgh, Christiaan

AU - Manini, Todd M.

AU - Marsh, Anthony P.

AU - Pahor, Marco

AU - Tudor-Locke, Catrine

AU - Conroy, David E.

AU - Buford, Thomas W.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Objectives: To examine associations between objectively measured physical activity (PA) and incidence of major mobility disability (MMD) and persistent MMD (PMMD) in older adults in the Lifestyle Interventions and Independence for Elders (LIFE) Study. Design: Prospective cohort of individuals aged 65 and older undergoing structured PA intervention or health education. Setting: The LIFE Study was a multicenter (eight sites) randomized controlled trial designed to compare the efficacy of a long-term structured PA intervention with that of a health education (HE) program in reducing the incidence of MMD in mobility-limited older adults. Participants: LIFE Study participants (n = 1,590) had a mean age±standard deviation of 78.9 ± 5.2, low levels of PA, and measured mobility-relevant functional impairment at baseline. Measurements: Activity data were collected using hip-worn 7-day accelerometers at baseline and 6, 12, and 24 months after randomization to test for associations with incident MMD and PMMD (≥2 consecutive instances of MMD). Results: At baseline, every 30 minutes spent being sedentary (<100 accelerometry counts per minute) was associated with higher rate of subsequent MMD (10%) and PMMD (11%) events. Every 500 steps taken was associated with lower rate of MMD (15%) and PMMD (18%). Similar associations were observed when fitting accelerometry-based PA as a time-dependent variable. Conclusion: Accelerometry-based PA levels were strongly associated with MMD and PMMD events in older adults with limited mobility. These results support the importance of daily PA and lower amounts of sedentary time levels in this population and suggest that accelerometry may be a useful tool for assessing risk of mobility disability.

AB - Objectives: To examine associations between objectively measured physical activity (PA) and incidence of major mobility disability (MMD) and persistent MMD (PMMD) in older adults in the Lifestyle Interventions and Independence for Elders (LIFE) Study. Design: Prospective cohort of individuals aged 65 and older undergoing structured PA intervention or health education. Setting: The LIFE Study was a multicenter (eight sites) randomized controlled trial designed to compare the efficacy of a long-term structured PA intervention with that of a health education (HE) program in reducing the incidence of MMD in mobility-limited older adults. Participants: LIFE Study participants (n = 1,590) had a mean age±standard deviation of 78.9 ± 5.2, low levels of PA, and measured mobility-relevant functional impairment at baseline. Measurements: Activity data were collected using hip-worn 7-day accelerometers at baseline and 6, 12, and 24 months after randomization to test for associations with incident MMD and PMMD (≥2 consecutive instances of MMD). Results: At baseline, every 30 minutes spent being sedentary (<100 accelerometry counts per minute) was associated with higher rate of subsequent MMD (10%) and PMMD (11%) events. Every 500 steps taken was associated with lower rate of MMD (15%) and PMMD (18%). Similar associations were observed when fitting accelerometry-based PA as a time-dependent variable. Conclusion: Accelerometry-based PA levels were strongly associated with MMD and PMMD events in older adults with limited mobility. These results support the importance of daily PA and lower amounts of sedentary time levels in this population and suggest that accelerometry may be a useful tool for assessing risk of mobility disability.

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