Dextrose intravenous fluid therapy in labor reduces the length of the first stage of labor

Melissa Riegel, Johanna Quist-Nelson, Gabriele Saccone, Mariavittoria Locci, Vineet K. Shrivastava, Raed Salim, Allan Fisher, Lennart Nordstrom, Allen Kunselman, John Repke, Alex Fong, John Smulian, Serena Xodo, Neggin Mokhtari, Fulvio Zullo, Vincenzo Berghella

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The aim of this systematic review with meta-analysis was to evaluate the effect on length of labor when patients receive IVF with or without dextrose. Searches were performed in electronic databases from inception of each database to May 2018. Trials comparing intrapartum IVF containing dextrose (i.e. intervention group) with no dextrose or placebo (i.e. control group) were included. Only trials examining low-risk pregnancies in labor at ≥36 weeks were included. Studies were included regardless of oral intake restriction. The primary outcome was the length of total labor from randomization to delivery. The meta-analysis was performed using the random effects model. Sixteen trials (n = 2503 participants) were included in the meta-analysis. Women randomized in the IVF dextrose group did not have a statistically significant different length of total labor from randomization to delivery compared to IVF without dextrose (MD −38.33 min, 95% CI −88.23 to 11.57). IVF with dextrose decreased the length of the first stage (MD −75.81 min, 95% CI −120.67 to −30.95), but there was no change in the second stage. In summary, use of IVF with dextrose during labor in low-risk women at term does not affect total length of labor, but it does shorten the first stage of labor.

Original languageEnglish (US)
Pages (from-to)284-294
Number of pages11
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume228
DOIs
StatePublished - Sep 1 2018

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First Labor Stage
Fluid Therapy
Glucose
Meta-Analysis
Random Allocation
Databases
Placebos
Pregnancy
Control Groups

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Riegel, Melissa ; Quist-Nelson, Johanna ; Saccone, Gabriele ; Locci, Mariavittoria ; Shrivastava, Vineet K. ; Salim, Raed ; Fisher, Allan ; Nordstrom, Lennart ; Kunselman, Allen ; Repke, John ; Fong, Alex ; Smulian, John ; Xodo, Serena ; Mokhtari, Neggin ; Zullo, Fulvio ; Berghella, Vincenzo. / Dextrose intravenous fluid therapy in labor reduces the length of the first stage of labor. In: European Journal of Obstetrics and Gynecology and Reproductive Biology. 2018 ; Vol. 228. pp. 284-294.
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title = "Dextrose intravenous fluid therapy in labor reduces the length of the first stage of labor",
abstract = "The aim of this systematic review with meta-analysis was to evaluate the effect on length of labor when patients receive IVF with or without dextrose. Searches were performed in electronic databases from inception of each database to May 2018. Trials comparing intrapartum IVF containing dextrose (i.e. intervention group) with no dextrose or placebo (i.e. control group) were included. Only trials examining low-risk pregnancies in labor at ≥36 weeks were included. Studies were included regardless of oral intake restriction. The primary outcome was the length of total labor from randomization to delivery. The meta-analysis was performed using the random effects model. Sixteen trials (n = 2503 participants) were included in the meta-analysis. Women randomized in the IVF dextrose group did not have a statistically significant different length of total labor from randomization to delivery compared to IVF without dextrose (MD −38.33 min, 95{\%} CI −88.23 to 11.57). IVF with dextrose decreased the length of the first stage (MD −75.81 min, 95{\%} CI −120.67 to −30.95), but there was no change in the second stage. In summary, use of IVF with dextrose during labor in low-risk women at term does not affect total length of labor, but it does shorten the first stage of labor.",
author = "Melissa Riegel and Johanna Quist-Nelson and Gabriele Saccone and Mariavittoria Locci and Shrivastava, {Vineet K.} and Raed Salim and Allan Fisher and Lennart Nordstrom and Allen Kunselman and John Repke and Alex Fong and John Smulian and Serena Xodo and Neggin Mokhtari and Fulvio Zullo and Vincenzo Berghella",
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Riegel, M, Quist-Nelson, J, Saccone, G, Locci, M, Shrivastava, VK, Salim, R, Fisher, A, Nordstrom, L, Kunselman, A, Repke, J, Fong, A, Smulian, J, Xodo, S, Mokhtari, N, Zullo, F & Berghella, V 2018, 'Dextrose intravenous fluid therapy in labor reduces the length of the first stage of labor', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 228, pp. 284-294. https://doi.org/10.1016/j.ejogrb.2018.07.019

Dextrose intravenous fluid therapy in labor reduces the length of the first stage of labor. / Riegel, Melissa; Quist-Nelson, Johanna; Saccone, Gabriele; Locci, Mariavittoria; Shrivastava, Vineet K.; Salim, Raed; Fisher, Allan; Nordstrom, Lennart; Kunselman, Allen; Repke, John; Fong, Alex; Smulian, John; Xodo, Serena; Mokhtari, Neggin; Zullo, Fulvio; Berghella, Vincenzo.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 228, 01.09.2018, p. 284-294.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Dextrose intravenous fluid therapy in labor reduces the length of the first stage of labor

AU - Riegel, Melissa

AU - Quist-Nelson, Johanna

AU - Saccone, Gabriele

AU - Locci, Mariavittoria

AU - Shrivastava, Vineet K.

AU - Salim, Raed

AU - Fisher, Allan

AU - Nordstrom, Lennart

AU - Kunselman, Allen

AU - Repke, John

AU - Fong, Alex

AU - Smulian, John

AU - Xodo, Serena

AU - Mokhtari, Neggin

AU - Zullo, Fulvio

AU - Berghella, Vincenzo

PY - 2018/9/1

Y1 - 2018/9/1

N2 - The aim of this systematic review with meta-analysis was to evaluate the effect on length of labor when patients receive IVF with or without dextrose. Searches were performed in electronic databases from inception of each database to May 2018. Trials comparing intrapartum IVF containing dextrose (i.e. intervention group) with no dextrose or placebo (i.e. control group) were included. Only trials examining low-risk pregnancies in labor at ≥36 weeks were included. Studies were included regardless of oral intake restriction. The primary outcome was the length of total labor from randomization to delivery. The meta-analysis was performed using the random effects model. Sixteen trials (n = 2503 participants) were included in the meta-analysis. Women randomized in the IVF dextrose group did not have a statistically significant different length of total labor from randomization to delivery compared to IVF without dextrose (MD −38.33 min, 95% CI −88.23 to 11.57). IVF with dextrose decreased the length of the first stage (MD −75.81 min, 95% CI −120.67 to −30.95), but there was no change in the second stage. In summary, use of IVF with dextrose during labor in low-risk women at term does not affect total length of labor, but it does shorten the first stage of labor.

AB - The aim of this systematic review with meta-analysis was to evaluate the effect on length of labor when patients receive IVF with or without dextrose. Searches were performed in electronic databases from inception of each database to May 2018. Trials comparing intrapartum IVF containing dextrose (i.e. intervention group) with no dextrose or placebo (i.e. control group) were included. Only trials examining low-risk pregnancies in labor at ≥36 weeks were included. Studies were included regardless of oral intake restriction. The primary outcome was the length of total labor from randomization to delivery. The meta-analysis was performed using the random effects model. Sixteen trials (n = 2503 participants) were included in the meta-analysis. Women randomized in the IVF dextrose group did not have a statistically significant different length of total labor from randomization to delivery compared to IVF without dextrose (MD −38.33 min, 95% CI −88.23 to 11.57). IVF with dextrose decreased the length of the first stage (MD −75.81 min, 95% CI −120.67 to −30.95), but there was no change in the second stage. In summary, use of IVF with dextrose during labor in low-risk women at term does not affect total length of labor, but it does shorten the first stage of labor.

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JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

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