TY - JOUR
T1 - Diabetes following acute pancreatitis
AU - Hart, Phil A.
AU - Bradley, David
AU - Conwell, Darwin L.
AU - Dungan, Kathleen
AU - Krishna, Somashekar G.
AU - Wyne, Kathleen
AU - Bellin, Melena D.
AU - Yadav, Dhiraj
AU - Andersen, Dana K.
AU - Serrano, Jose
AU - Papachristou, Georgios I.
N1 - Funding Information:
Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers U01DK127388 (PAH, DB, DLC, KD, GIP), U01DK108327 (PAH, DB, DLC), U01DK126300 (MDB), U01DK127367 (MDB), U01DK108306 (DY), and U01DK127377 (DY). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/8
Y1 - 2021/8
N2 - Diabetes represents a group of diseases involving persistent hyperglycaemia. Exocrine disorders of the pancreas are increasingly recognised to cause or precede the onset of diabetes, which in this context is referred to as pancreatogenic or type 3c diabetes. Diabetes, as a sequela of acute pancreatitis, is observed across the spectrum of severity in acute pancreatitis and can be associated with other clinical complications. The pathophysiology of acute pancreatitis-related diabetes is poorly understood, and observations suggest that it is probably multifactorial. In this Review, we discuss the epidemiology, pathophysiology, and management considerations of diabetes following acute pancreatitis, and highlight knowledge gaps in this topic.
AB - Diabetes represents a group of diseases involving persistent hyperglycaemia. Exocrine disorders of the pancreas are increasingly recognised to cause or precede the onset of diabetes, which in this context is referred to as pancreatogenic or type 3c diabetes. Diabetes, as a sequela of acute pancreatitis, is observed across the spectrum of severity in acute pancreatitis and can be associated with other clinical complications. The pathophysiology of acute pancreatitis-related diabetes is poorly understood, and observations suggest that it is probably multifactorial. In this Review, we discuss the epidemiology, pathophysiology, and management considerations of diabetes following acute pancreatitis, and highlight knowledge gaps in this topic.
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U2 - 10.1016/S2468-1253(21)00019-4
DO - 10.1016/S2468-1253(21)00019-4
M3 - Review article
C2 - 34089654
AN - SCOPUS:85109446721
VL - 6
SP - 668
EP - 675
JO - The Lancet Gastroenterology and Hepatology
JF - The Lancet Gastroenterology and Hepatology
SN - 2468-1253
IS - 8
ER -
