Diabetic retinopathy: recent advances towards understanding neurodegeneration and vision loss

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Diabetic retinopathy (DR) is one of the most common retinal diseases world-wide. It has a complex pathology that involves the vasculature of the inner retina and breakdown of the blood-retinal barrier. Extensive research has determined that DR is not only a vascular disease but also has a neurodegenerative component and that essentially all types of cells in the retina are affected, leading to chronic loss of visual function. A great deal of work using animal models of DR has established the loss of neurons and pathology of other cell types, including supporting glial cells. There has also been an increased emphasis on measuring retinal function in the models, as well as further validation and extension of the animal studies by clinical and translational research. This article will attempt to summarize the more recent developments in research towards understanding the complexities of retinal neurodegeneration and functional vision loss in DR.

Original languageEnglish (US)
Pages (from-to)541-549
Number of pages9
JournalScience China Life Sciences
Volume58
Issue number6
DOIs
StatePublished - Jun 20 2015

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diabetic retinopathy
Diabetic Retinopathy
Pathology
pathology
Animals
retina
Retina
animal
Blood-Retinal Barrier
retinal diseases
Retinal Diseases
vascular diseases
Neurons
Translational Medical Research
neuroglia
Blood
blood
Vascular Diseases
Research
Neuroglia

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

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abstract = "Diabetic retinopathy (DR) is one of the most common retinal diseases world-wide. It has a complex pathology that involves the vasculature of the inner retina and breakdown of the blood-retinal barrier. Extensive research has determined that DR is not only a vascular disease but also has a neurodegenerative component and that essentially all types of cells in the retina are affected, leading to chronic loss of visual function. A great deal of work using animal models of DR has established the loss of neurons and pathology of other cell types, including supporting glial cells. There has also been an increased emphasis on measuring retinal function in the models, as well as further validation and extension of the animal studies by clinical and translational research. This article will attempt to summarize the more recent developments in research towards understanding the complexities of retinal neurodegeneration and functional vision loss in DR.",
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Diabetic retinopathy : recent advances towards understanding neurodegeneration and vision loss. / Barber, Alistair J.

In: Science China Life Sciences, Vol. 58, No. 6, 20.06.2015, p. 541-549.

Research output: Contribution to journalReview article

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