Diazonamide synthesis studies: Use of negishi coupling to fashion diazonamide-related biaryls with defined axial chirality

Ken S. Feldman, Kyle J. Eastman, Guillaume Lessene

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

(matrix presented) The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp3 stereogenic center in a lactone tether in both cases.

Original languageEnglish (US)
Pages (from-to)3525-3528
Number of pages4
JournalOrganic Letters
Volume4
Issue number20
DOIs
StatePublished - Oct 3 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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