Dietary iron intake and risk of Parkinson's disease

Giancarlo Logroscino, Xiang Gao, Honglei Chen, Al Wing, Alberto Ascherio

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Dietary iron is the most important source of iron stores. Several case-control studies have described the association of high dietary iron and Parkinson's disease, but prospective data are lacking. The authors prospectively followed 47,406 men and 76,947 women from the United States who provided information through a mailed questionnaire on their diet, medical history, and lifestyle practices between 1984 and 2000. The authors documented 422 new cases of Parkinson's disease. Total iron intake was not associated with an increased risk of Parkinson's disease (relative risk (RR) = 1.10, 95% confidence interval (CI): 0.74, 1.65; Ptrend = 0.84), but dietary nonheme iron intake from food was associated with a 30% increased risk of Parkinson's disease (RR = 1.27, 95% CI: 0.92, 1.76; Ptrend = 0.02). A secondary analysis revealed that Parkinson's disease risk was significantly increased among individuals with high nonheme iron and low vitamin C intakes (RR = 1.92, 95% CI: 1.14, 3.32; Ptrend = 0.002). Supplemental iron intake was associated with a borderline increase in Parkinson's disease risk among men. Although the authors' prospective data did not support an association between total iron intake (dietary and supplemental) and risk of Parkinson's disease, a 30% increased risk was associated with a diet rich in nonheme iron. This increase in risk was present in those who had low vitamin C intake.

Original languageEnglish (US)
Pages (from-to)1381-1388
Number of pages8
JournalAmerican journal of epidemiology
Volume168
Issue number12
DOIs
StatePublished - Dec 1 2008

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Dietary Iron
Parkinson Disease
Iron
Confidence Intervals
Ascorbic Acid
Diet
Case-Control Studies
Life Style
Eating

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Logroscino, Giancarlo ; Gao, Xiang ; Chen, Honglei ; Wing, Al ; Ascherio, Alberto. / Dietary iron intake and risk of Parkinson's disease. In: American journal of epidemiology. 2008 ; Vol. 168, No. 12. pp. 1381-1388.
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abstract = "Dietary iron is the most important source of iron stores. Several case-control studies have described the association of high dietary iron and Parkinson's disease, but prospective data are lacking. The authors prospectively followed 47,406 men and 76,947 women from the United States who provided information through a mailed questionnaire on their diet, medical history, and lifestyle practices between 1984 and 2000. The authors documented 422 new cases of Parkinson's disease. Total iron intake was not associated with an increased risk of Parkinson's disease (relative risk (RR) = 1.10, 95{\%} confidence interval (CI): 0.74, 1.65; Ptrend = 0.84), but dietary nonheme iron intake from food was associated with a 30{\%} increased risk of Parkinson's disease (RR = 1.27, 95{\%} CI: 0.92, 1.76; Ptrend = 0.02). A secondary analysis revealed that Parkinson's disease risk was significantly increased among individuals with high nonheme iron and low vitamin C intakes (RR = 1.92, 95{\%} CI: 1.14, 3.32; Ptrend = 0.002). Supplemental iron intake was associated with a borderline increase in Parkinson's disease risk among men. Although the authors' prospective data did not support an association between total iron intake (dietary and supplemental) and risk of Parkinson's disease, a 30{\%} increased risk was associated with a diet rich in nonheme iron. This increase in risk was present in those who had low vitamin C intake.",
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Logroscino, G, Gao, X, Chen, H, Wing, A & Ascherio, A 2008, 'Dietary iron intake and risk of Parkinson's disease', American journal of epidemiology, vol. 168, no. 12, pp. 1381-1388. https://doi.org/10.1093/aje/kwn273

Dietary iron intake and risk of Parkinson's disease. / Logroscino, Giancarlo; Gao, Xiang; Chen, Honglei; Wing, Al; Ascherio, Alberto.

In: American journal of epidemiology, Vol. 168, No. 12, 01.12.2008, p. 1381-1388.

Research output: Contribution to journalArticle

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