Dietary modification of chyle composition in chylothorax

Gordon Lee Jensen, Edward A. Mascioli, Laura P. Meyer, Sarah M. Lopes, Stacey J. Bell, Vigen K. Babayan, George L. Blackburn, Bruce R. Bistrian

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Nutrition support has played a major role in the treatment of chylothorax, both to prevent malnutrition and to minimize chyle production and flow. This report evaluates chyle composition in a patient with chylothorax who was placed on a low-fat diet, medium-chain triglyceride diet, and total parenteral nutrition in sequence. Both triglyceride content and volume of chyle declined, but drainage persisted, ultimately requiring thoracic duct ligation. The chyle triglyceride while on total parenteral nutrition, which presumably originates from both the intestine and plasma, contained more long-chain unsaturated fatty acids than the circulating serum triglyceride. Of particular interest was the detection of an appreciable amount of medium-chain fatty acids in the chyle triglyceride, constituting 20% of the triglyceride fatty acids when an enteral formulation with medium-chain triglyceride as a sole fat source was administered. The finding of almost threefold more decanoic acid (C10:0) than octanoic acid (C8:0), despite the presence of considerably more octanoic acid in the original diet, suggests that trioctanoin may be a preferable medium-chain triglyceride substrate for the nonsurgical treatment of chylothorax.

Original languageEnglish (US)
Pages (from-to)761-765
Number of pages5
JournalGastroenterology
Volume97
Issue number3
DOIs
StatePublished - Jan 1 1989

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Chyle
Chylothorax
Diet Therapy
Triglycerides
Total Parenteral Nutrition
Fatty Acids
Diet
Thoracic Duct
Fat-Restricted Diet
Unsaturated Fatty Acids
Malnutrition
Small Intestine
Intestines
Ligation
Drainage
Fats

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Jensen, G. L., Mascioli, E. A., Meyer, L. P., Lopes, S. M., Bell, S. J., Babayan, V. K., ... Bistrian, B. R. (1989). Dietary modification of chyle composition in chylothorax. Gastroenterology, 97(3), 761-765. https://doi.org/10.1016/0016-5085(89)90650-1
Jensen, Gordon Lee ; Mascioli, Edward A. ; Meyer, Laura P. ; Lopes, Sarah M. ; Bell, Stacey J. ; Babayan, Vigen K. ; Blackburn, George L. ; Bistrian, Bruce R. / Dietary modification of chyle composition in chylothorax. In: Gastroenterology. 1989 ; Vol. 97, No. 3. pp. 761-765.
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Jensen, GL, Mascioli, EA, Meyer, LP, Lopes, SM, Bell, SJ, Babayan, VK, Blackburn, GL & Bistrian, BR 1989, 'Dietary modification of chyle composition in chylothorax', Gastroenterology, vol. 97, no. 3, pp. 761-765. https://doi.org/10.1016/0016-5085(89)90650-1

Dietary modification of chyle composition in chylothorax. / Jensen, Gordon Lee; Mascioli, Edward A.; Meyer, Laura P.; Lopes, Sarah M.; Bell, Stacey J.; Babayan, Vigen K.; Blackburn, George L.; Bistrian, Bruce R.

In: Gastroenterology, Vol. 97, No. 3, 01.01.1989, p. 761-765.

Research output: Contribution to journalArticle

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Jensen GL, Mascioli EA, Meyer LP, Lopes SM, Bell SJ, Babayan VK et al. Dietary modification of chyle composition in chylothorax. Gastroenterology. 1989 Jan 1;97(3):761-765. https://doi.org/10.1016/0016-5085(89)90650-1