Dietary predictors of arterial stiffness in a cohort with type 1 and type 2 diabetes

K. S. Petersen, J. B. Keogh, P. J. Meikle, M. L. Garg, P. M. Clifton

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To determine the dietary predictors of central blood pressure, augmentation index and pulse wave velocity (PWV) in subjects with type 1 and type 2 diabetes. Methods: Participants were diagnosed with type 1 or type 2 diabetes and had PWV and/or pulse wave analysis performed. Dietary intake was measured using the Dietary Questionnaire for Epidemiological Studies Version 2 Food Frequency Questionnaire. Serum lipid species and carotenoids were measured, using liquid chromatography electrospray ionization-tandem mass spectrometry and high performance liquid chromatography, as biomarkers of dairy and vegetable intake, respectively. Associations were determined using linear regression adjusted for potential confounders. Results: PWV ( n=95) was inversely associated with reduced fat dairy intake ( β=-0.01; 95% CI-0.02,-0.01; p=0<0.05) in particular yoghurt consumption ( β=-0.04; 95% CI-0.09,-0.01; p=0<0.05) after multivariate adjustment. Total vegetable consumption was negatively associated with PWV in the whole cohort after full adjustment ( β=-0.04; 95% CI-0.07,-0.01; p<0.05). Individual lipid species, particularly those containing 14:0, 15:0, 16:0, 17:0 and 17:1 fatty acids, known to be of ruminant origin, in lysophosphatidylcholine, cholesterol ester, diacylglycerol, phosphatidylcholine, sphingomyelin and triacylglycerol classes were positively associated with intake of full fat dairy, after adjustment for multiple comparisons. However, there was no association between serum lipid species and PWV. There were no dietary predictors of central blood pressure or augmentation index after multivariate adjustment. Conclusion: In this cohort of subjects with diabetes reduced fat dairy intake and vegetable consumption were inversely associated with PWV. The lack of a relationship between serum lipid species and PWV suggests that the fatty acid composition of dairy may not explain the beneficial effect.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalAtherosclerosis
Volume238
Issue number2
DOIs
StatePublished - Feb 1 2015

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Pulse Wave Analysis
Vascular Stiffness
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Vegetables
Lipids
Fats
Fatty Acids
Serum
Blood Pressure
Yogurt
Lysophosphatidylcholines
Sphingomyelins
Electrospray Ionization Mass Spectrometry
Cholesterol Esters
Diglycerides
Ruminants
Carotenoids
Tandem Mass Spectrometry
Phosphatidylcholines

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Petersen, K. S. ; Keogh, J. B. ; Meikle, P. J. ; Garg, M. L. ; Clifton, P. M. / Dietary predictors of arterial stiffness in a cohort with type 1 and type 2 diabetes. In: Atherosclerosis. 2015 ; Vol. 238, No. 2. pp. 175-181.
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abstract = "Objective: To determine the dietary predictors of central blood pressure, augmentation index and pulse wave velocity (PWV) in subjects with type 1 and type 2 diabetes. Methods: Participants were diagnosed with type 1 or type 2 diabetes and had PWV and/or pulse wave analysis performed. Dietary intake was measured using the Dietary Questionnaire for Epidemiological Studies Version 2 Food Frequency Questionnaire. Serum lipid species and carotenoids were measured, using liquid chromatography electrospray ionization-tandem mass spectrometry and high performance liquid chromatography, as biomarkers of dairy and vegetable intake, respectively. Associations were determined using linear regression adjusted for potential confounders. Results: PWV ( n=95) was inversely associated with reduced fat dairy intake ( β=-0.01; 95{\%} CI-0.02,-0.01; p=0<0.05) in particular yoghurt consumption ( β=-0.04; 95{\%} CI-0.09,-0.01; p=0<0.05) after multivariate adjustment. Total vegetable consumption was negatively associated with PWV in the whole cohort after full adjustment ( β=-0.04; 95{\%} CI-0.07,-0.01; p<0.05). Individual lipid species, particularly those containing 14:0, 15:0, 16:0, 17:0 and 17:1 fatty acids, known to be of ruminant origin, in lysophosphatidylcholine, cholesterol ester, diacylglycerol, phosphatidylcholine, sphingomyelin and triacylglycerol classes were positively associated with intake of full fat dairy, after adjustment for multiple comparisons. However, there was no association between serum lipid species and PWV. There were no dietary predictors of central blood pressure or augmentation index after multivariate adjustment. Conclusion: In this cohort of subjects with diabetes reduced fat dairy intake and vegetable consumption were inversely associated with PWV. The lack of a relationship between serum lipid species and PWV suggests that the fatty acid composition of dairy may not explain the beneficial effect.",
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Dietary predictors of arterial stiffness in a cohort with type 1 and type 2 diabetes. / Petersen, K. S.; Keogh, J. B.; Meikle, P. J.; Garg, M. L.; Clifton, P. M.

In: Atherosclerosis, Vol. 238, No. 2, 01.02.2015, p. 175-181.

Research output: Contribution to journalArticle

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AU - Petersen, K. S.

AU - Keogh, J. B.

AU - Meikle, P. J.

AU - Garg, M. L.

AU - Clifton, P. M.

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N2 - Objective: To determine the dietary predictors of central blood pressure, augmentation index and pulse wave velocity (PWV) in subjects with type 1 and type 2 diabetes. Methods: Participants were diagnosed with type 1 or type 2 diabetes and had PWV and/or pulse wave analysis performed. Dietary intake was measured using the Dietary Questionnaire for Epidemiological Studies Version 2 Food Frequency Questionnaire. Serum lipid species and carotenoids were measured, using liquid chromatography electrospray ionization-tandem mass spectrometry and high performance liquid chromatography, as biomarkers of dairy and vegetable intake, respectively. Associations were determined using linear regression adjusted for potential confounders. Results: PWV ( n=95) was inversely associated with reduced fat dairy intake ( β=-0.01; 95% CI-0.02,-0.01; p=0<0.05) in particular yoghurt consumption ( β=-0.04; 95% CI-0.09,-0.01; p=0<0.05) after multivariate adjustment. Total vegetable consumption was negatively associated with PWV in the whole cohort after full adjustment ( β=-0.04; 95% CI-0.07,-0.01; p<0.05). Individual lipid species, particularly those containing 14:0, 15:0, 16:0, 17:0 and 17:1 fatty acids, known to be of ruminant origin, in lysophosphatidylcholine, cholesterol ester, diacylglycerol, phosphatidylcholine, sphingomyelin and triacylglycerol classes were positively associated with intake of full fat dairy, after adjustment for multiple comparisons. However, there was no association between serum lipid species and PWV. There were no dietary predictors of central blood pressure or augmentation index after multivariate adjustment. Conclusion: In this cohort of subjects with diabetes reduced fat dairy intake and vegetable consumption were inversely associated with PWV. The lack of a relationship between serum lipid species and PWV suggests that the fatty acid composition of dairy may not explain the beneficial effect.

AB - Objective: To determine the dietary predictors of central blood pressure, augmentation index and pulse wave velocity (PWV) in subjects with type 1 and type 2 diabetes. Methods: Participants were diagnosed with type 1 or type 2 diabetes and had PWV and/or pulse wave analysis performed. Dietary intake was measured using the Dietary Questionnaire for Epidemiological Studies Version 2 Food Frequency Questionnaire. Serum lipid species and carotenoids were measured, using liquid chromatography electrospray ionization-tandem mass spectrometry and high performance liquid chromatography, as biomarkers of dairy and vegetable intake, respectively. Associations were determined using linear regression adjusted for potential confounders. Results: PWV ( n=95) was inversely associated with reduced fat dairy intake ( β=-0.01; 95% CI-0.02,-0.01; p=0<0.05) in particular yoghurt consumption ( β=-0.04; 95% CI-0.09,-0.01; p=0<0.05) after multivariate adjustment. Total vegetable consumption was negatively associated with PWV in the whole cohort after full adjustment ( β=-0.04; 95% CI-0.07,-0.01; p<0.05). Individual lipid species, particularly those containing 14:0, 15:0, 16:0, 17:0 and 17:1 fatty acids, known to be of ruminant origin, in lysophosphatidylcholine, cholesterol ester, diacylglycerol, phosphatidylcholine, sphingomyelin and triacylglycerol classes were positively associated with intake of full fat dairy, after adjustment for multiple comparisons. However, there was no association between serum lipid species and PWV. There were no dietary predictors of central blood pressure or augmentation index after multivariate adjustment. Conclusion: In this cohort of subjects with diabetes reduced fat dairy intake and vegetable consumption were inversely associated with PWV. The lack of a relationship between serum lipid species and PWV suggests that the fatty acid composition of dairy may not explain the beneficial effect.

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