Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity

Kate J. Bowen, Penny Margaret Kris-Etherton, Sheila Grace West, Jennifer Anne Fleming, Philip W. Connelly, Benoît Lamarche, Patrick Couture, David J.A. Jenkins, Carla G. Taylor, Peter Zahradka, Shatha S. Hammad, Jyoti Sihag, Xiang Chen, Valérie Guay, Julie Maltais-Giguère, Danielle Perera, Angela Wilson, Sandra Castillo San Juan, Julia Rempel, Peter J.H. Jones

Research output: Contribution to journalArticle

Abstract

Background: Novel oils high in monounsaturated fatty acids (MUFAs) and low in saturated fatty acids (SFAs) are an alternative to partially hydrogenated oils high in trans-unsaturated fatty acids. There is widespread use of high-MUFA oils across the food industry; however, limited knowledge of their cardiovascular impact exists. Objective: We investigated the effects of diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) on lipids, lipoproteins, and apolipoproteins (apos), as secondary outcomes of the trial. Methods: In a multi-center, double-blind, randomized, 3-period crossover, controlled feeding trial, men (n = 44) and women (n = 75) with a mean age of 44 y, mean body mass index (BMI; in kg/m2) of 31.7, and an increased waist circumference plus ≥1 metabolic syndrome criteria consumed prepared, weight-maintenance diets containing canola oil [17.5% MUFAs, 9.2% polyunsaturated fatty acids (PUFAs), 6.6% SFAs], HOCO (19.1% MUFAs, 7.0% PUFAs, 6.4% SFAs), or control oil (10.5% MUFAs, 10.0% PUFAs, 12.3% SFAs) for 6 wk with ≥4-wk washouts. Fasting serum lipids were assessed at baseline and 6 wk. Diet effects were examined using a repeated measures mixed model. Results: Compared with the control, canola and HOCO diets resulted in lower endpoint total cholesterol (TC; −4.2% and −3.4%; P < 0.0001), LDL cholesterol (−6.6% and −5.6%; P < 0.0001), apoB (−3.7% and −3.4%; P = 0.002), and non-HDL cholesterol (−4.5% and −4.0%; P = 0.001), with no differences between canola diets. The TC:HDL cholesterol and apoB:apoA1 ratios were lower after the HOCO diet than after the control diet (−3.7% and −3.4%, respectively). There were no diet effects on triglyceride, HDL cholesterol, or apoA1 concentrations. Conclusions: HOCO, with increased MUFAs at the expense of decreased PUFAs, elicited beneficial effects on lipids and lipoproteins comparable to conventional canola oil and consistent with reduced cardiovascular disease risk in adults with central adiposity.

Original languageEnglish (US)
Pages (from-to)471-478
Number of pages8
JournalJournal of Nutrition
Volume149
Issue number3
DOIs
StatePublished - Mar 1 2019

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Adiposity
Oleic Acid
Lipoproteins
Monounsaturated Fatty Acids
Fatty Acids
Diet
Lipids
Unsaturated Fatty Acids
Oils
Apolipoproteins B
HDL Cholesterol
Cholesterol
Trans Fatty Acids
canola oil
Apolipoproteins
Food Industry
Waist Circumference
LDL Cholesterol
Fasting
Triglycerides

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Bowen, Kate J. ; Kris-Etherton, Penny Margaret ; West, Sheila Grace ; Fleming, Jennifer Anne ; Connelly, Philip W. ; Lamarche, Benoît ; Couture, Patrick ; Jenkins, David J.A. ; Taylor, Carla G. ; Zahradka, Peter ; Hammad, Shatha S. ; Sihag, Jyoti ; Chen, Xiang ; Guay, Valérie ; Maltais-Giguère, Julie ; Perera, Danielle ; Wilson, Angela ; Juan, Sandra Castillo San ; Rempel, Julia ; Jones, Peter J.H. / Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. In: Journal of Nutrition. 2019 ; Vol. 149, No. 3. pp. 471-478.
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title = "Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity",
abstract = "Background: Novel oils high in monounsaturated fatty acids (MUFAs) and low in saturated fatty acids (SFAs) are an alternative to partially hydrogenated oils high in trans-unsaturated fatty acids. There is widespread use of high-MUFA oils across the food industry; however, limited knowledge of their cardiovascular impact exists. Objective: We investigated the effects of diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) on lipids, lipoproteins, and apolipoproteins (apos), as secondary outcomes of the trial. Methods: In a multi-center, double-blind, randomized, 3-period crossover, controlled feeding trial, men (n = 44) and women (n = 75) with a mean age of 44 y, mean body mass index (BMI; in kg/m2) of 31.7, and an increased waist circumference plus ≥1 metabolic syndrome criteria consumed prepared, weight-maintenance diets containing canola oil [17.5{\%} MUFAs, 9.2{\%} polyunsaturated fatty acids (PUFAs), 6.6{\%} SFAs], HOCO (19.1{\%} MUFAs, 7.0{\%} PUFAs, 6.4{\%} SFAs), or control oil (10.5{\%} MUFAs, 10.0{\%} PUFAs, 12.3{\%} SFAs) for 6 wk with ≥4-wk washouts. Fasting serum lipids were assessed at baseline and 6 wk. Diet effects were examined using a repeated measures mixed model. Results: Compared with the control, canola and HOCO diets resulted in lower endpoint total cholesterol (TC; −4.2{\%} and −3.4{\%}; P < 0.0001), LDL cholesterol (−6.6{\%} and −5.6{\%}; P < 0.0001), apoB (−3.7{\%} and −3.4{\%}; P = 0.002), and non-HDL cholesterol (−4.5{\%} and −4.0{\%}; P = 0.001), with no differences between canola diets. The TC:HDL cholesterol and apoB:apoA1 ratios were lower after the HOCO diet than after the control diet (−3.7{\%} and −3.4{\%}, respectively). There were no diet effects on triglyceride, HDL cholesterol, or apoA1 concentrations. Conclusions: HOCO, with increased MUFAs at the expense of decreased PUFAs, elicited beneficial effects on lipids and lipoproteins comparable to conventional canola oil and consistent with reduced cardiovascular disease risk in adults with central adiposity.",
author = "Bowen, {Kate J.} and Kris-Etherton, {Penny Margaret} and West, {Sheila Grace} and Fleming, {Jennifer Anne} and Connelly, {Philip W.} and Beno{\^i}t Lamarche and Patrick Couture and Jenkins, {David J.A.} and Taylor, {Carla G.} and Peter Zahradka and Hammad, {Shatha S.} and Jyoti Sihag and Xiang Chen and Val{\'e}rie Guay and Julie Maltais-Gigu{\`e}re and Danielle Perera and Angela Wilson and Juan, {Sandra Castillo San} and Julia Rempel and Jones, {Peter J.H.}",
year = "2019",
month = "3",
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doi = "10.1093/jn/nxy307",
language = "English (US)",
volume = "149",
pages = "471--478",
journal = "Journal of Nutrition",
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Bowen, KJ, Kris-Etherton, PM, West, SG, Fleming, JA, Connelly, PW, Lamarche, B, Couture, P, Jenkins, DJA, Taylor, CG, Zahradka, P, Hammad, SS, Sihag, J, Chen, X, Guay, V, Maltais-Giguère, J, Perera, D, Wilson, A, Juan, SCS, Rempel, J & Jones, PJH 2019, 'Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity', Journal of Nutrition, vol. 149, no. 3, pp. 471-478. https://doi.org/10.1093/jn/nxy307

Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. / Bowen, Kate J.; Kris-Etherton, Penny Margaret; West, Sheila Grace; Fleming, Jennifer Anne; Connelly, Philip W.; Lamarche, Benoît; Couture, Patrick; Jenkins, David J.A.; Taylor, Carla G.; Zahradka, Peter; Hammad, Shatha S.; Sihag, Jyoti; Chen, Xiang; Guay, Valérie; Maltais-Giguère, Julie; Perera, Danielle; Wilson, Angela; Juan, Sandra Castillo San; Rempel, Julia; Jones, Peter J.H.

In: Journal of Nutrition, Vol. 149, No. 3, 01.03.2019, p. 471-478.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity

AU - Bowen, Kate J.

AU - Kris-Etherton, Penny Margaret

AU - West, Sheila Grace

AU - Fleming, Jennifer Anne

AU - Connelly, Philip W.

AU - Lamarche, Benoît

AU - Couture, Patrick

AU - Jenkins, David J.A.

AU - Taylor, Carla G.

AU - Zahradka, Peter

AU - Hammad, Shatha S.

AU - Sihag, Jyoti

AU - Chen, Xiang

AU - Guay, Valérie

AU - Maltais-Giguère, Julie

AU - Perera, Danielle

AU - Wilson, Angela

AU - Juan, Sandra Castillo San

AU - Rempel, Julia

AU - Jones, Peter J.H.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: Novel oils high in monounsaturated fatty acids (MUFAs) and low in saturated fatty acids (SFAs) are an alternative to partially hydrogenated oils high in trans-unsaturated fatty acids. There is widespread use of high-MUFA oils across the food industry; however, limited knowledge of their cardiovascular impact exists. Objective: We investigated the effects of diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) on lipids, lipoproteins, and apolipoproteins (apos), as secondary outcomes of the trial. Methods: In a multi-center, double-blind, randomized, 3-period crossover, controlled feeding trial, men (n = 44) and women (n = 75) with a mean age of 44 y, mean body mass index (BMI; in kg/m2) of 31.7, and an increased waist circumference plus ≥1 metabolic syndrome criteria consumed prepared, weight-maintenance diets containing canola oil [17.5% MUFAs, 9.2% polyunsaturated fatty acids (PUFAs), 6.6% SFAs], HOCO (19.1% MUFAs, 7.0% PUFAs, 6.4% SFAs), or control oil (10.5% MUFAs, 10.0% PUFAs, 12.3% SFAs) for 6 wk with ≥4-wk washouts. Fasting serum lipids were assessed at baseline and 6 wk. Diet effects were examined using a repeated measures mixed model. Results: Compared with the control, canola and HOCO diets resulted in lower endpoint total cholesterol (TC; −4.2% and −3.4%; P < 0.0001), LDL cholesterol (−6.6% and −5.6%; P < 0.0001), apoB (−3.7% and −3.4%; P = 0.002), and non-HDL cholesterol (−4.5% and −4.0%; P = 0.001), with no differences between canola diets. The TC:HDL cholesterol and apoB:apoA1 ratios were lower after the HOCO diet than after the control diet (−3.7% and −3.4%, respectively). There were no diet effects on triglyceride, HDL cholesterol, or apoA1 concentrations. Conclusions: HOCO, with increased MUFAs at the expense of decreased PUFAs, elicited beneficial effects on lipids and lipoproteins comparable to conventional canola oil and consistent with reduced cardiovascular disease risk in adults with central adiposity.

AB - Background: Novel oils high in monounsaturated fatty acids (MUFAs) and low in saturated fatty acids (SFAs) are an alternative to partially hydrogenated oils high in trans-unsaturated fatty acids. There is widespread use of high-MUFA oils across the food industry; however, limited knowledge of their cardiovascular impact exists. Objective: We investigated the effects of diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) on lipids, lipoproteins, and apolipoproteins (apos), as secondary outcomes of the trial. Methods: In a multi-center, double-blind, randomized, 3-period crossover, controlled feeding trial, men (n = 44) and women (n = 75) with a mean age of 44 y, mean body mass index (BMI; in kg/m2) of 31.7, and an increased waist circumference plus ≥1 metabolic syndrome criteria consumed prepared, weight-maintenance diets containing canola oil [17.5% MUFAs, 9.2% polyunsaturated fatty acids (PUFAs), 6.6% SFAs], HOCO (19.1% MUFAs, 7.0% PUFAs, 6.4% SFAs), or control oil (10.5% MUFAs, 10.0% PUFAs, 12.3% SFAs) for 6 wk with ≥4-wk washouts. Fasting serum lipids were assessed at baseline and 6 wk. Diet effects were examined using a repeated measures mixed model. Results: Compared with the control, canola and HOCO diets resulted in lower endpoint total cholesterol (TC; −4.2% and −3.4%; P < 0.0001), LDL cholesterol (−6.6% and −5.6%; P < 0.0001), apoB (−3.7% and −3.4%; P = 0.002), and non-HDL cholesterol (−4.5% and −4.0%; P = 0.001), with no differences between canola diets. The TC:HDL cholesterol and apoB:apoA1 ratios were lower after the HOCO diet than after the control diet (−3.7% and −3.4%, respectively). There were no diet effects on triglyceride, HDL cholesterol, or apoA1 concentrations. Conclusions: HOCO, with increased MUFAs at the expense of decreased PUFAs, elicited beneficial effects on lipids and lipoproteins comparable to conventional canola oil and consistent with reduced cardiovascular disease risk in adults with central adiposity.

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