Difference in body weight between American and Italian women with polycystic ovary syndrome: Influence of the diet

Enrico Carmina, Richard Legro, Kelly Stamets, Jennifer Lowell, Rogerio A. Lobo

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Background: The study aim was to determine differences in body mass in two populations of women (USA and Italy) with polycystic ovary syndrome (PCOS), and to assess the effect of diet on body mass and cardiovascular risk factors. Methods: Pools of women with PCOS from the USA (n = 343) and Italy (n = 301), seen between 1993 and 2001, were available for assessment. From these populations, 20 women who were seen consecutively in 2001 at each site had detailed analyses of diet and cardiovascular risk factors. Results: In the entire group, American women had a significantly higher body mass compared with Italian women (P < 0.01). Also, the 20 women consecutively evaluated in the USA had a significantly higher mean (± SD) body mass index (40.3 ± 1.0 kg/m2) than in Italy (29.7 ± 1.0 kg/m2). US women had worse insulin resistance, lower levels of high-density lipoprotein-cholesterol (HDL-C) (P < 0.01) and higher levels of triglycerides (P < 0.01). Dietary analysis in the two groups indicated that the total daily calorific intake was similar (USA 2277 ± 109; Italy 2325 ± 68 Kcal), with no appreciable differences in dietary content of protein, carbohydrate and fat. However, the dietary saturated fat content was significantly higher in US women (31.9 ± 3 versus 18.2 ± 2 g/day, P < 0.01). Saturated fat intake correlated negatively with HDL-C (P < 0.01). Conclusions: Among women with PCOS, body mass was significantly higher in US women compared with Italian women. However, total calorie intake and dietary constituents were similar, except for a higher saturated fat in US women. It is hypothesized that diet alone does not explain differences in body mass; genetic and lifestyle factors likely contribute. An increased saturated fat intake may worsen the cardiovascular risk profile.

Original languageEnglish (US)
Pages (from-to)2289-2293
Number of pages5
JournalHuman Reproduction
Volume18
Issue number11
DOIs
StatePublished - Jan 1 2003

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Polycystic Ovary Syndrome
Body Weight
Diet
Italy
Dietary Fats
Fats
HDL Cholesterol
Dietary Proteins
Population
Insulin Resistance
Life Style
Triglycerides
Body Mass Index
Carbohydrates

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Carmina, Enrico ; Legro, Richard ; Stamets, Kelly ; Lowell, Jennifer ; Lobo, Rogerio A. / Difference in body weight between American and Italian women with polycystic ovary syndrome : Influence of the diet. In: Human Reproduction. 2003 ; Vol. 18, No. 11. pp. 2289-2293.
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abstract = "Background: The study aim was to determine differences in body mass in two populations of women (USA and Italy) with polycystic ovary syndrome (PCOS), and to assess the effect of diet on body mass and cardiovascular risk factors. Methods: Pools of women with PCOS from the USA (n = 343) and Italy (n = 301), seen between 1993 and 2001, were available for assessment. From these populations, 20 women who were seen consecutively in 2001 at each site had detailed analyses of diet and cardiovascular risk factors. Results: In the entire group, American women had a significantly higher body mass compared with Italian women (P < 0.01). Also, the 20 women consecutively evaluated in the USA had a significantly higher mean (± SD) body mass index (40.3 ± 1.0 kg/m2) than in Italy (29.7 ± 1.0 kg/m2). US women had worse insulin resistance, lower levels of high-density lipoprotein-cholesterol (HDL-C) (P < 0.01) and higher levels of triglycerides (P < 0.01). Dietary analysis in the two groups indicated that the total daily calorific intake was similar (USA 2277 ± 109; Italy 2325 ± 68 Kcal), with no appreciable differences in dietary content of protein, carbohydrate and fat. However, the dietary saturated fat content was significantly higher in US women (31.9 ± 3 versus 18.2 ± 2 g/day, P < 0.01). Saturated fat intake correlated negatively with HDL-C (P < 0.01). Conclusions: Among women with PCOS, body mass was significantly higher in US women compared with Italian women. However, total calorie intake and dietary constituents were similar, except for a higher saturated fat in US women. It is hypothesized that diet alone does not explain differences in body mass; genetic and lifestyle factors likely contribute. An increased saturated fat intake may worsen the cardiovascular risk profile.",
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Difference in body weight between American and Italian women with polycystic ovary syndrome : Influence of the diet. / Carmina, Enrico; Legro, Richard; Stamets, Kelly; Lowell, Jennifer; Lobo, Rogerio A.

In: Human Reproduction, Vol. 18, No. 11, 01.01.2003, p. 2289-2293.

Research output: Contribution to journalArticle

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T1 - Difference in body weight between American and Italian women with polycystic ovary syndrome

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AB - Background: The study aim was to determine differences in body mass in two populations of women (USA and Italy) with polycystic ovary syndrome (PCOS), and to assess the effect of diet on body mass and cardiovascular risk factors. Methods: Pools of women with PCOS from the USA (n = 343) and Italy (n = 301), seen between 1993 and 2001, were available for assessment. From these populations, 20 women who were seen consecutively in 2001 at each site had detailed analyses of diet and cardiovascular risk factors. Results: In the entire group, American women had a significantly higher body mass compared with Italian women (P < 0.01). Also, the 20 women consecutively evaluated in the USA had a significantly higher mean (± SD) body mass index (40.3 ± 1.0 kg/m2) than in Italy (29.7 ± 1.0 kg/m2). US women had worse insulin resistance, lower levels of high-density lipoprotein-cholesterol (HDL-C) (P < 0.01) and higher levels of triglycerides (P < 0.01). Dietary analysis in the two groups indicated that the total daily calorific intake was similar (USA 2277 ± 109; Italy 2325 ± 68 Kcal), with no appreciable differences in dietary content of protein, carbohydrate and fat. However, the dietary saturated fat content was significantly higher in US women (31.9 ± 3 versus 18.2 ± 2 g/day, P < 0.01). Saturated fat intake correlated negatively with HDL-C (P < 0.01). Conclusions: Among women with PCOS, body mass was significantly higher in US women compared with Italian women. However, total calorie intake and dietary constituents were similar, except for a higher saturated fat in US women. It is hypothesized that diet alone does not explain differences in body mass; genetic and lifestyle factors likely contribute. An increased saturated fat intake may worsen the cardiovascular risk profile.

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