Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate

Marie Claude Clemencet, Giuliana Muzio, Antonella Trombetta, Jeffrey M. Peters, Frank J. Gonzalez, Rosa A. Canuto, Norbert Latruffe

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Abstract

Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human and rat response to peroxisome proliferators were evaluated using rat and human tumour liver cell lines. Rat 7777 cells were more responsive than human HepG2 cells to ciprofibrate as they exhibited a higher decrease in cell number than HepG2, and underwent apoptosis. Results from these studies reveal a surprising response in tumour cell lines as the typical in vivo response of increased cell proliferation and reduced apoptosis was not observed in rat tumour cell lines at concentrations greater than those used to elicit the former response.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalCancer Letters
Volume222
Issue number2
DOIs
StatePublished - May 26 2005

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Clemencet, M. C., Muzio, G., Trombetta, A., Peters, J. M., Gonzalez, F. J., Canuto, R. A., & Latruffe, N. (2005). Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate. Cancer Letters, 222(2), 217-226. https://doi.org/10.1016/j.canlet.2004.09.016