Differences in galectin-3, a biomarker of fibrosis, between participants with peripheral artery disease and participants with normal ankle-brachial index

Ana I. Casanegra, Julie A. Stoner, Alfonso J. Tafur, H. Anne Pereira, Suman W. Rathbun, Andrew W. Gardner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this study was to determine if galectin-3 levels were different between participants with peripheral artery disease (PAD) and controls, and to describe its relationship with markers of early atherosclerosis. Sixty participants were recruited into two groups: a PAD group (n=31), ankle-brachial index (ABI) ≤0.90 and a normal ABI group (n=29), ABI 1.0-1.4. PAD participants were older (68.6 vs 61.8 years, p=0.037), more commonly men (68% vs 38%, p=0.02), and with more cardiovascular risk factors (p<0.001). Galectin-3 was 22% higher in PAD participants (mean±SD: 17.6±4.7 vs 14.4±4.1 ng/mL, p<0.01). The odds ratio for galectin-3 in PAD to be 1 ng/mL higher than the participants with normal ABI was 1.19, after adjusting by age and gender (p=0.014). High-sensitivity C-reactive protein (hs-CRP) and homeostatic model assessment (HOMA) were positively associated with galectin-3 in the age- and gender-adjusted model, while arterial elasticity and microalbuminuria were not. In conclusion, galectin-3 levels were higher in participants with PAD.

Original languageEnglish (US)
Pages (from-to)437-444
Number of pages8
JournalVascular Medicine (United Kingdom)
Volume21
Issue number5
DOIs
StatePublished - Oct 1 2016

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Galectin 3
Ankle Brachial Index
Peripheral Arterial Disease
Fibrosis
Biomarkers
Elasticity
C-Reactive Protein
Atherosclerosis
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Casanegra, Ana I. ; Stoner, Julie A. ; Tafur, Alfonso J. ; Pereira, H. Anne ; Rathbun, Suman W. ; Gardner, Andrew W. / Differences in galectin-3, a biomarker of fibrosis, between participants with peripheral artery disease and participants with normal ankle-brachial index. In: Vascular Medicine (United Kingdom). 2016 ; Vol. 21, No. 5. pp. 437-444.
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abstract = "The aim of this study was to determine if galectin-3 levels were different between participants with peripheral artery disease (PAD) and controls, and to describe its relationship with markers of early atherosclerosis. Sixty participants were recruited into two groups: a PAD group (n=31), ankle-brachial index (ABI) ≤0.90 and a normal ABI group (n=29), ABI 1.0-1.4. PAD participants were older (68.6 vs 61.8 years, p=0.037), more commonly men (68{\%} vs 38{\%}, p=0.02), and with more cardiovascular risk factors (p<0.001). Galectin-3 was 22{\%} higher in PAD participants (mean±SD: 17.6±4.7 vs 14.4±4.1 ng/mL, p<0.01). The odds ratio for galectin-3 in PAD to be 1 ng/mL higher than the participants with normal ABI was 1.19, after adjusting by age and gender (p=0.014). High-sensitivity C-reactive protein (hs-CRP) and homeostatic model assessment (HOMA) were positively associated with galectin-3 in the age- and gender-adjusted model, while arterial elasticity and microalbuminuria were not. In conclusion, galectin-3 levels were higher in participants with PAD.",
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Differences in galectin-3, a biomarker of fibrosis, between participants with peripheral artery disease and participants with normal ankle-brachial index. / Casanegra, Ana I.; Stoner, Julie A.; Tafur, Alfonso J.; Pereira, H. Anne; Rathbun, Suman W.; Gardner, Andrew W.

In: Vascular Medicine (United Kingdom), Vol. 21, No. 5, 01.10.2016, p. 437-444.

Research output: Contribution to journalArticle

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AU - Casanegra, Ana I.

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AU - Gardner, Andrew W.

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