Differences in the expression of histocompatibility antigen-DR and in anti-Mycobacterial activity of monocytes from HIV-infected individuals

Bruce S. Zwilling, Janelle Salkowitz, Harry Laufman, Dennis Keith Pearl

Research output: Contribution to journalArticle

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Abstract

This study assesses the changes in the expression of histocompatibility antigen (HLA)-DR by mononuclear phagocytes from HIV-infected individuals. Overnight culture of monocytes resulted in an increase in HLA-DR expression by monocytes from uninfected individuals. In contrast, the expression of HLA-DR by monocytes from HIV-infected patients decreased spontaneously and was most pronounced in patients with clinical AIDS. We also found that Mycobacterium avium grew within monocytes from patients infected with HIV. The correlation between major histocompatibility complex (MHC) class II expression and Mycobacterial growth which has been reported in mice was not observed in monocytes from HIV-infected patients.

Original languageEnglish (US)
Pages (from-to)1327-1332
Number of pages6
JournalAIDS
Volume5
Issue number11
DOIs
Publication statusPublished - Jan 1 1991

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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