Different effects of CCK antagonists on gastric-acid response to CCK and pentagastrin

R. L. Corwin, G. P. Smith

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The role of CCK receptor subtypes in peptide-stimulated acid secretion was assessed in six unanesthetized rats. The CCK-stimulated acid secretion was not blocked by L-365,260, a CCKB/gastrin receptor antagonist, and was significantly increased by devazepide, a CCKA receptor antagonist, give alone or together with L-365,260. L-365,260, but not devazepide, blocked pentagastrin-stimulated acid secretion, and, when given together, devazepide abolished the effect of L-365,260. We conclude: 1) pentagastrin stimulates acid secretion through a gastrin-type receptor, but CCK may not, and 2) pentagastrin and CCK can stimulate acid secretion despite simultaneous blockade of CCKB/gastrin and CCKA receptors.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalPeptides
Volume14
Issue number2
DOIs
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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