Differential actions of classical and atypical antipsychotic drugs on spontaneous neuronal activity in the amygdaloid complex

George V. Rebec, Kevin D. Alloway, Theodore R. Bashore

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Classical antipsychotic drugs such as haloperidol produce akinesia and catalepsy, whereas clozapine and related atypical antipsychotics fail to elicit these behaviors even at relatively high doses. Despite these behavioral differences, a cataleptic dose of haloperidol (2.0 mg/kg) produces changes in neuronal activity in the neostriatum and nucleus accumbens comparable to those produced by a non-cataleptic dose of clozapine (20.0 mg/kg). To further elucidate the brain mechanisms underlying the differential behavioral response to these drugs, an electrophysiological analysis was extended to neurons in the rat amygdaloid complex. Whereas an intraperitoneal injection of 2.0 mg/kg haloperidol generally failed to alter the firing rate of amygdaloid neurons, 20.0 mg/kg clozapine typically produced a prolonged increase in activity. Similarly, clozapine, but not haloperidol, reversed the depression of firing rate produced by 1.0 mg/kg d-amphetamine. The results suggest that neurons in the amygdaloid complex are more responsive to antipsychotic drugs devoid of extrapyramidal side effects than to antipsychotics which elicit parkinsonian-like motor dysfunctions.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalPharmacology, Biochemistry and Behavior
Volume14
Issue number1
DOIs
StatePublished - Jan 1981

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Clozapine
Haloperidol
Antipsychotic Agents
Neurons
Catalepsy
Neostriatum
Dextroamphetamine
Nucleus Accumbens
Intraperitoneal Injections
Rats
Brain
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

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Differential actions of classical and atypical antipsychotic drugs on spontaneous neuronal activity in the amygdaloid complex. / Rebec, George V.; Alloway, Kevin D.; Bashore, Theodore R.

In: Pharmacology, Biochemistry and Behavior, Vol. 14, No. 1, 01.1981, p. 49-56.

Research output: Contribution to journalArticle

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