Differential effects of gonadal function on bone histomorphometry in male and female rats

Russell T. Turner, Kathleen S. Hannon, Laurence M. Demers, James Buchanan, Norman H. Bell

Research output: Contribution to journalArticle

153 Scopus citations

Abstract

The effects of castration on bone histomorphometry and mineral homeostasis were compared in male and female rats. Measurements were performed 4 weeks after sham operation or gonadectomy. Orchiectomy produced increases in serum calcium and decreases in serum testosterone and androstenedione, whereas ovariectomy produced decreases in serum estradiol and testosterone. Orchiectomy did not alter static bone histomorphometric measurements of the tibial diaphysis, whereas ovariectomy increased cross‐sectional and medullary areas, lowered endosteal tetracycline‐labeled surface length, and markedly increased endosteal nonlabeled surface length. Orchiectomy decreased mean periosteal bone formation rate and mean periosteal bone apposition rate, whereas ovariectomy increased both measurements. Orchiectomy and ovariectomy markedly diminished trabecular area and trabecular surface length at the tibial metaphysis. Orchiectomy did not alter the number of osteoclasts per mm trabecular surface or the percentage of trabecular surface covered by osteoclasts, whereas ovariectomy increased both measurements. These findings indicate that gonadal hormones produce separate and distinct effects on bone metabolism as determined by histomorphometry in male and female rats.

Original languageEnglish (US)
Pages (from-to)557-563
Number of pages7
JournalJournal of Bone and Mineral Research
Volume4
Issue number4
DOIs
StatePublished - Aug 1989

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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