Abstract
Background: Nicotine exposure affects the hippocampus through activation of hippocampal nicotinic acetylcholine receptors (nAChRs), which are present throughout excitatory and inhibitory hippocampal circuitry. The role of cholinergic functioning in the hippocampus varies across developmental stages so that nicotine exposure differentially affects this region depending upon timing of exposure, producing developmentally distinct changes in structure, function, and behavior. Methods: We synthesize findings across literature in this area to comprehensively review current understanding of the unique effects of nicotine exposure on the hippocampus throughout the lifespan with a focus on hippocampal morphology, cholinergic functioning, and hippocampus-dependent learning and memory. Conclusions: Chronic and acute nicotine exposure differentially affect hippocampus structure, functioning, and related learning and memory in the perinatal period, adolescence, and aging. Age-related differences in sensitivity to nicotine exposure should be considered in the research of nicotine addiction and the development of nicotine addiction treatments.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 388-402 |
| Number of pages | 15 |
| Journal | Current Neuropharmacology |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2018 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Pharmacology (medical)
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Differential effects of nicotine exposure on the hippocampus across lifespan. / Zeid, Dana; Kutlu, Munir Gunes; Gould, Thomas J.
In: Current Neuropharmacology, Vol. 16, No. 4, 01.01.2018, p. 388-402.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Differential effects of nicotine exposure on the hippocampus across lifespan
AU - Zeid, Dana
AU - Kutlu, Munir Gunes
AU - Gould, Thomas J.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Nicotine exposure affects the hippocampus through activation of hippocampal nicotinic acetylcholine receptors (nAChRs), which are present throughout excitatory and inhibitory hippocampal circuitry. The role of cholinergic functioning in the hippocampus varies across developmental stages so that nicotine exposure differentially affects this region depending upon timing of exposure, producing developmentally distinct changes in structure, function, and behavior. Methods: We synthesize findings across literature in this area to comprehensively review current understanding of the unique effects of nicotine exposure on the hippocampus throughout the lifespan with a focus on hippocampal morphology, cholinergic functioning, and hippocampus-dependent learning and memory. Conclusions: Chronic and acute nicotine exposure differentially affect hippocampus structure, functioning, and related learning and memory in the perinatal period, adolescence, and aging. Age-related differences in sensitivity to nicotine exposure should be considered in the research of nicotine addiction and the development of nicotine addiction treatments.
AB - Background: Nicotine exposure affects the hippocampus through activation of hippocampal nicotinic acetylcholine receptors (nAChRs), which are present throughout excitatory and inhibitory hippocampal circuitry. The role of cholinergic functioning in the hippocampus varies across developmental stages so that nicotine exposure differentially affects this region depending upon timing of exposure, producing developmentally distinct changes in structure, function, and behavior. Methods: We synthesize findings across literature in this area to comprehensively review current understanding of the unique effects of nicotine exposure on the hippocampus throughout the lifespan with a focus on hippocampal morphology, cholinergic functioning, and hippocampus-dependent learning and memory. Conclusions: Chronic and acute nicotine exposure differentially affect hippocampus structure, functioning, and related learning and memory in the perinatal period, adolescence, and aging. Age-related differences in sensitivity to nicotine exposure should be considered in the research of nicotine addiction and the development of nicotine addiction treatments.
UR - http://www.scopus.com/inward/record.url?scp=85048986920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048986920&partnerID=8YFLogxK
U2 - 10.2174/1570159X15666170714092436
DO - 10.2174/1570159X15666170714092436
M3 - Review article
C2 - 28714396
AN - SCOPUS:85048986920
VL - 16
SP - 388
EP - 402
JO - Current Neuropharmacology
JF - Current Neuropharmacology
SN - 1570-159X
IS - 4
ER -