Differential Effects of TRH, Amphetamine, Naloxone, and Fenmetozole on Ethanol Actions

Attenuation of the Effects of Punishment and Impairment of Aerial Righting Reflex

R. A. Vogel, G. D. Frye, K. Mann Koepke, Richard Mailman, R. A. Mueller, G. R. Breese

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effects of four putative ethanol antagonists [thyrotropin releasing hormone (TRH), naloxone, d‐amphetamine, and fenmetozole] on two distinct behavioral actions of ethanol were compared. TRH (20–40 mg/kg) reduced ethanol‐induced impairment of the aerial righting reflex (ARR) but enhanced the ethanol‐induced increase in punished drinking (anticonflict effect). Naloxone antagonized both actions of ethanol but only at high doses (20–60 mg/kg). Amphetamine (1–4 mg/kg) abolished the ethanol effect on punished drinking but did not alter its impairment of the ARR (1 ‐8 mg/kg). Conversely, fenmetozole antagonized the ethanol impairment of the ARR (15–30 mg/kg) but not ethanol's anticonflict action. The inconsistent pattern of “antagonist” interactions of these drugs with the behavioral actions of ethanol suggests that ethanol alters several neurochemical systems to produce its behavioral effects.

Original languageEnglish (US)
Pages (from-to)386-392
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1981

Fingerprint

Righting Reflex
Thyrotropin-Releasing Hormone
Punishment
Amphetamine
Naloxone
Ethanol
Antennas
Drinking
fenmetazole
Drug Interactions

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

@article{39cb28497c3e4a37b7b2961e2b36fed2,
title = "Differential Effects of TRH, Amphetamine, Naloxone, and Fenmetozole on Ethanol Actions: Attenuation of the Effects of Punishment and Impairment of Aerial Righting Reflex",
abstract = "The effects of four putative ethanol antagonists [thyrotropin releasing hormone (TRH), naloxone, d‐amphetamine, and fenmetozole] on two distinct behavioral actions of ethanol were compared. TRH (20–40 mg/kg) reduced ethanol‐induced impairment of the aerial righting reflex (ARR) but enhanced the ethanol‐induced increase in punished drinking (anticonflict effect). Naloxone antagonized both actions of ethanol but only at high doses (20–60 mg/kg). Amphetamine (1–4 mg/kg) abolished the ethanol effect on punished drinking but did not alter its impairment of the ARR (1 ‐8 mg/kg). Conversely, fenmetozole antagonized the ethanol impairment of the ARR (15–30 mg/kg) but not ethanol's anticonflict action. The inconsistent pattern of “antagonist” interactions of these drugs with the behavioral actions of ethanol suggests that ethanol alters several neurochemical systems to produce its behavioral effects.",
author = "Vogel, {R. A.} and Frye, {G. D.} and Koepke, {K. Mann} and Richard Mailman and Mueller, {R. A.} and Breese, {G. R.}",
year = "1981",
month = "1",
day = "1",
doi = "10.1111/j.1530-0277.1981.tb04921.x",
language = "English (US)",
volume = "5",
pages = "386--392",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "3",

}

Differential Effects of TRH, Amphetamine, Naloxone, and Fenmetozole on Ethanol Actions : Attenuation of the Effects of Punishment and Impairment of Aerial Righting Reflex. / Vogel, R. A.; Frye, G. D.; Koepke, K. Mann; Mailman, Richard; Mueller, R. A.; Breese, G. R.

In: Alcoholism: Clinical and Experimental Research, Vol. 5, No. 3, 01.01.1981, p. 386-392.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential Effects of TRH, Amphetamine, Naloxone, and Fenmetozole on Ethanol Actions

T2 - Attenuation of the Effects of Punishment and Impairment of Aerial Righting Reflex

AU - Vogel, R. A.

AU - Frye, G. D.

AU - Koepke, K. Mann

AU - Mailman, Richard

AU - Mueller, R. A.

AU - Breese, G. R.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - The effects of four putative ethanol antagonists [thyrotropin releasing hormone (TRH), naloxone, d‐amphetamine, and fenmetozole] on two distinct behavioral actions of ethanol were compared. TRH (20–40 mg/kg) reduced ethanol‐induced impairment of the aerial righting reflex (ARR) but enhanced the ethanol‐induced increase in punished drinking (anticonflict effect). Naloxone antagonized both actions of ethanol but only at high doses (20–60 mg/kg). Amphetamine (1–4 mg/kg) abolished the ethanol effect on punished drinking but did not alter its impairment of the ARR (1 ‐8 mg/kg). Conversely, fenmetozole antagonized the ethanol impairment of the ARR (15–30 mg/kg) but not ethanol's anticonflict action. The inconsistent pattern of “antagonist” interactions of these drugs with the behavioral actions of ethanol suggests that ethanol alters several neurochemical systems to produce its behavioral effects.

AB - The effects of four putative ethanol antagonists [thyrotropin releasing hormone (TRH), naloxone, d‐amphetamine, and fenmetozole] on two distinct behavioral actions of ethanol were compared. TRH (20–40 mg/kg) reduced ethanol‐induced impairment of the aerial righting reflex (ARR) but enhanced the ethanol‐induced increase in punished drinking (anticonflict effect). Naloxone antagonized both actions of ethanol but only at high doses (20–60 mg/kg). Amphetamine (1–4 mg/kg) abolished the ethanol effect on punished drinking but did not alter its impairment of the ARR (1 ‐8 mg/kg). Conversely, fenmetozole antagonized the ethanol impairment of the ARR (15–30 mg/kg) but not ethanol's anticonflict action. The inconsistent pattern of “antagonist” interactions of these drugs with the behavioral actions of ethanol suggests that ethanol alters several neurochemical systems to produce its behavioral effects.

UR - http://www.scopus.com/inward/record.url?scp=0019465455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019465455&partnerID=8YFLogxK

U2 - 10.1111/j.1530-0277.1981.tb04921.x

DO - 10.1111/j.1530-0277.1981.tb04921.x

M3 - Article

VL - 5

SP - 386

EP - 392

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 3

ER -