Differentiation of etiologic agents of bacterial keratitis from presentation characteristics

Jeena Mascarenhas, Muthiah Srinivasan, Michael Chen, Revathi Rajaraman, Meenakshi Ravindran, Prajna Lalitha, Catherine E. Oldenburg, Kathryn J. Ray, David V. Glidden, Stephanie Costanza, Thomas M. Lietman, Nisha R. Acharya

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Presenting characteristics of bacterial corneal ulcers may suggest particular causative organisms, helping to guide treatment decisions before cultures become available. In this study, we analyze the association between presentation demographic and clinical characteristics, using data collected as part of a randomized, controlled clinical trial. Data for this study were collected as part of the Steroids for Corneal Ulcers Trial, a randomized, placebo-controlled, double-masked trial. All patients had a culture-proven bacterial corneal ulcer. Patient history, clinical examination, and photography were performed in a standardized fashion at enrollment. Analysis of variance or Fisher's exact test was used to compare characteristics by organism. Univariate logistic regression was used to analyze predictors of the most common organisms. Five hundred patients were enrolled in the trial, of whom 488 were included in this analysis. The most common organism was Streptococcus pneumoniae (N = 248, 51 %) followed by Pseudomonas aeruginosa (N = 110, 23 %). Compared to other organisms, P. aeruginosa was significantly associated with a larger baseline infiltrate/scar size [odds ratio (OR) 1.6, 95 % confidence interval (CI) 1.4-1.8] and deeper infiltrate (OR 2.4, 95 % CI 1.5-3.8). S. pneumoniae was significantly associated with a smaller baseline infiltrate/scar size (OR 0.8, 95 % CI 0.7-0.9) and dacryocystitis (OR 7.3, 95 % CI 4.1-13.3). Nocardia spp. were significantly associated with longer duration of symptoms prior to presentation (OR 1.4, 95 % CI 1.2-1.6), more shallow infiltrate (OR 0.3, 95 % CI 0.2-0.5), and better baseline visual acuity (OR 0.4, 95 % CI 0.2-0.65). Staphylococcus spp. were less likely to be central in location (OR 0.16, 95 % CI 0.08-0.3). Baseline characteristics of bacterial ulcers may suggest the likely etiology and guide early management.

Original languageEnglish (US)
Pages (from-to)531-538
Number of pages8
JournalInternational Ophthalmology
Volume32
Issue number6
DOIs
StatePublished - Dec 1 2012

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Keratitis
Odds Ratio
Confidence Intervals
Corneal Ulcer
Streptococcus pneumoniae
Pseudomonas aeruginosa
Cicatrix
Dacryocystitis
Nocardia
Photography
Staphylococcus
Visual Acuity
Ulcer
Analysis of Variance
Randomized Controlled Trials
Logistic Models
Steroids
Placebos
Demography

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Mascarenhas, J., Srinivasan, M., Chen, M., Rajaraman, R., Ravindran, M., Lalitha, P., ... Acharya, N. R. (2012). Differentiation of etiologic agents of bacterial keratitis from presentation characteristics. International Ophthalmology, 32(6), 531-538. https://doi.org/10.1007/s10792-012-9601-x
Mascarenhas, Jeena ; Srinivasan, Muthiah ; Chen, Michael ; Rajaraman, Revathi ; Ravindran, Meenakshi ; Lalitha, Prajna ; Oldenburg, Catherine E. ; Ray, Kathryn J. ; Glidden, David V. ; Costanza, Stephanie ; Lietman, Thomas M. ; Acharya, Nisha R. / Differentiation of etiologic agents of bacterial keratitis from presentation characteristics. In: International Ophthalmology. 2012 ; Vol. 32, No. 6. pp. 531-538.
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abstract = "Presenting characteristics of bacterial corneal ulcers may suggest particular causative organisms, helping to guide treatment decisions before cultures become available. In this study, we analyze the association between presentation demographic and clinical characteristics, using data collected as part of a randomized, controlled clinical trial. Data for this study were collected as part of the Steroids for Corneal Ulcers Trial, a randomized, placebo-controlled, double-masked trial. All patients had a culture-proven bacterial corneal ulcer. Patient history, clinical examination, and photography were performed in a standardized fashion at enrollment. Analysis of variance or Fisher's exact test was used to compare characteristics by organism. Univariate logistic regression was used to analyze predictors of the most common organisms. Five hundred patients were enrolled in the trial, of whom 488 were included in this analysis. The most common organism was Streptococcus pneumoniae (N = 248, 51 {\%}) followed by Pseudomonas aeruginosa (N = 110, 23 {\%}). Compared to other organisms, P. aeruginosa was significantly associated with a larger baseline infiltrate/scar size [odds ratio (OR) 1.6, 95 {\%} confidence interval (CI) 1.4-1.8] and deeper infiltrate (OR 2.4, 95 {\%} CI 1.5-3.8). S. pneumoniae was significantly associated with a smaller baseline infiltrate/scar size (OR 0.8, 95 {\%} CI 0.7-0.9) and dacryocystitis (OR 7.3, 95 {\%} CI 4.1-13.3). Nocardia spp. were significantly associated with longer duration of symptoms prior to presentation (OR 1.4, 95 {\%} CI 1.2-1.6), more shallow infiltrate (OR 0.3, 95 {\%} CI 0.2-0.5), and better baseline visual acuity (OR 0.4, 95 {\%} CI 0.2-0.65). Staphylococcus spp. were less likely to be central in location (OR 0.16, 95 {\%} CI 0.08-0.3). Baseline characteristics of bacterial ulcers may suggest the likely etiology and guide early management.",
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Mascarenhas, J, Srinivasan, M, Chen, M, Rajaraman, R, Ravindran, M, Lalitha, P, Oldenburg, CE, Ray, KJ, Glidden, DV, Costanza, S, Lietman, TM & Acharya, NR 2012, 'Differentiation of etiologic agents of bacterial keratitis from presentation characteristics', International Ophthalmology, vol. 32, no. 6, pp. 531-538. https://doi.org/10.1007/s10792-012-9601-x

Differentiation of etiologic agents of bacterial keratitis from presentation characteristics. / Mascarenhas, Jeena; Srinivasan, Muthiah; Chen, Michael; Rajaraman, Revathi; Ravindran, Meenakshi; Lalitha, Prajna; Oldenburg, Catherine E.; Ray, Kathryn J.; Glidden, David V.; Costanza, Stephanie; Lietman, Thomas M.; Acharya, Nisha R.

In: International Ophthalmology, Vol. 32, No. 6, 01.12.2012, p. 531-538.

Research output: Contribution to journalArticle

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T1 - Differentiation of etiologic agents of bacterial keratitis from presentation characteristics

AU - Mascarenhas, Jeena

AU - Srinivasan, Muthiah

AU - Chen, Michael

AU - Rajaraman, Revathi

AU - Ravindran, Meenakshi

AU - Lalitha, Prajna

AU - Oldenburg, Catherine E.

AU - Ray, Kathryn J.

AU - Glidden, David V.

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AU - Lietman, Thomas M.

AU - Acharya, Nisha R.

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