Diffuse large B-cell lymphoma of the prostate

Joshua Warrick, Scott R. Owens, Scott A. Tomlins

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

In this article, we review prostatic lymphomas and discuss the differential diagnosis of high-grade malignant neoplasms of the prostate. We illustrate this with a case of a 46-year-old man seen with lower urinary tract obstruction who had diffuse involvement by a high-grade malignancy on prostate biopsy. Morphologic evaluation and immunohistochemistry were consistent with diffuse large B-cell lymphoma of the prostate. Workup with positron emission tomography-computed tomography demonstrated intensely hypermetabolic lymph nodes in the mediastinum, as well as widespread osseous involvement and involvement of the pancreatic tail, prostate, and urinary bladder, suggesting secondary prostatic involvement by a nodal lymphoma. Lymphomas of the prostate are uncommon in surgical pathology practice and usually represent secondary involvement from leukemia/lymphoma at a more typical site. Chronic lymphocytic leukemia/ small lymphocytic lymphoma is the most common subtype.

Original languageEnglish (US)
Pages (from-to)1286-1289
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume138
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Prostate
Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Surgical Pathology
Mediastinum
Urinary Tract
Prostatic Neoplasms
Leukemia
Urinary Bladder
Differential Diagnosis
Lymph Nodes
Immunohistochemistry
Biopsy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology
  • Medicine(all)

Cite this

Warrick, Joshua ; Owens, Scott R. ; Tomlins, Scott A. / Diffuse large B-cell lymphoma of the prostate. In: Archives of Pathology and Laboratory Medicine. 2014 ; Vol. 138, No. 10. pp. 1286-1289.
@article{4b9cc1448fd94395bbc25b4a821f11ec,
title = "Diffuse large B-cell lymphoma of the prostate",
abstract = "In this article, we review prostatic lymphomas and discuss the differential diagnosis of high-grade malignant neoplasms of the prostate. We illustrate this with a case of a 46-year-old man seen with lower urinary tract obstruction who had diffuse involvement by a high-grade malignancy on prostate biopsy. Morphologic evaluation and immunohistochemistry were consistent with diffuse large B-cell lymphoma of the prostate. Workup with positron emission tomography-computed tomography demonstrated intensely hypermetabolic lymph nodes in the mediastinum, as well as widespread osseous involvement and involvement of the pancreatic tail, prostate, and urinary bladder, suggesting secondary prostatic involvement by a nodal lymphoma. Lymphomas of the prostate are uncommon in surgical pathology practice and usually represent secondary involvement from leukemia/lymphoma at a more typical site. Chronic lymphocytic leukemia/ small lymphocytic lymphoma is the most common subtype.",
author = "Joshua Warrick and Owens, {Scott R.} and Tomlins, {Scott A.}",
year = "2014",
month = "10",
day = "1",
doi = "10.5858/arpa.2014-0276-CC",
language = "English (US)",
volume = "138",
pages = "1286--1289",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "10",

}

Diffuse large B-cell lymphoma of the prostate. / Warrick, Joshua; Owens, Scott R.; Tomlins, Scott A.

In: Archives of Pathology and Laboratory Medicine, Vol. 138, No. 10, 01.10.2014, p. 1286-1289.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Diffuse large B-cell lymphoma of the prostate

AU - Warrick, Joshua

AU - Owens, Scott R.

AU - Tomlins, Scott A.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - In this article, we review prostatic lymphomas and discuss the differential diagnosis of high-grade malignant neoplasms of the prostate. We illustrate this with a case of a 46-year-old man seen with lower urinary tract obstruction who had diffuse involvement by a high-grade malignancy on prostate biopsy. Morphologic evaluation and immunohistochemistry were consistent with diffuse large B-cell lymphoma of the prostate. Workup with positron emission tomography-computed tomography demonstrated intensely hypermetabolic lymph nodes in the mediastinum, as well as widespread osseous involvement and involvement of the pancreatic tail, prostate, and urinary bladder, suggesting secondary prostatic involvement by a nodal lymphoma. Lymphomas of the prostate are uncommon in surgical pathology practice and usually represent secondary involvement from leukemia/lymphoma at a more typical site. Chronic lymphocytic leukemia/ small lymphocytic lymphoma is the most common subtype.

AB - In this article, we review prostatic lymphomas and discuss the differential diagnosis of high-grade malignant neoplasms of the prostate. We illustrate this with a case of a 46-year-old man seen with lower urinary tract obstruction who had diffuse involvement by a high-grade malignancy on prostate biopsy. Morphologic evaluation and immunohistochemistry were consistent with diffuse large B-cell lymphoma of the prostate. Workup with positron emission tomography-computed tomography demonstrated intensely hypermetabolic lymph nodes in the mediastinum, as well as widespread osseous involvement and involvement of the pancreatic tail, prostate, and urinary bladder, suggesting secondary prostatic involvement by a nodal lymphoma. Lymphomas of the prostate are uncommon in surgical pathology practice and usually represent secondary involvement from leukemia/lymphoma at a more typical site. Chronic lymphocytic leukemia/ small lymphocytic lymphoma is the most common subtype.

UR - http://www.scopus.com/inward/record.url?scp=84907612264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907612264&partnerID=8YFLogxK

U2 - 10.5858/arpa.2014-0276-CC

DO - 10.5858/arpa.2014-0276-CC

M3 - Review article

C2 - 25268190

AN - SCOPUS:84907612264

VL - 138

SP - 1286

EP - 1289

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 10

ER -