Diffuse large B-cell lymphoma with coexpression of CD3 in a pediatric patient: A case report, review of the literature, and tissue microarray study

Jeremy C. Wallentine, Sherrie L. Perkins, Sheryl R. Tripp, Richard D. Bruggman, Michael G. Bayerl

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The aberrant expression of T-cell antigens on B-cell-derived non-Hodgkin lymphomas has been described. However, the expression of the lineage-specific T-cell antigen, CD3, in hematologic malignancies is exceedingly rare and to the best of our knowledge has not been reported in pediatric patients. Here we describe the first case of a CD3+ diffuse large B-cell lymphoma in a 9-year-old male patient that is well documented by immunohistochemistry. In addition, results of a tissue microarray study composed of B-cell-derived non-Hodgkin lymphomas (n=77) and reactive lymphoid hyperplasia (n=13) dual stained for PAX5/CD3 are also reported.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2009

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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