Diffusion-controlled polymer dissolution and drug release

J. S. Vrentas, Christine Mary Vrentas

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Abstract

A model is formulated for diffusion-controlled polymer dissolution and simultaneous drug release for amorphous, uncrosslinked polymers. Calculated fractional drug release versus time curves are similar to experimental curves reported in the literature. Solutions of the transport equations provide a way of illustrating how polymer type and molecular weight can be used in an attempt to approach a constant drug release rate.

Original languageEnglish (US)
Pages (from-to)92-99
Number of pages8
JournalJournal of Applied Polymer Science
Volume93
Issue number1
DOIs
Publication statusPublished - Jul 5 2004

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

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