Dimension reduction strategies for analyzing global gene expression data with a response

Francesca Chiaromonte, Jessica Martinelli

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The analysis of global gene expression data from microarrays is breaking new ground in genetics research, while confronting modelers and statisticians with many critical issues. In this paper, we consider data sets in which a categorical or continuous response is recorded, along with gene expression, on a given number of experimental samples. Data of this type are usually employed to create a prediction mechanism for the response based on gene expression, and to identify a subset of relevant genes. This defines a regression setting characterized by a dramatic under-resolution with respect to the predictors (genes), whose number exceeds by orders of magnitude the number of available observations (samples). We present a dimension reduction strategy that, under appropriate assumptions, allows us to restrict attention to a few linear combinations of the original expression profiles, and thus to overcome under-resolution. These linear combinations can then be used to build and validate a regression model with standard techniques. Moreover, they can be used to rank original predictors, and ultimately to select a subset of them through comparison with a background 'chance scenario' based on a number of independent randomizations. We apply this strategy to publicly available data on leukemia classification.

Original languageEnglish (US)
Pages (from-to)123-144
Number of pages22
JournalMathematical Biosciences
Volume176
Issue number1
DOIs
StatePublished - Apr 3 2002

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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