[Diminished expression of CD5 and/or CD7 surface antigens as the first clue of diagnosis for monoclonal T lymphocytosis].

Hiroki Kawano, Kentaro Minagawa, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Toshimitsu Matsui, Yoshio Katayama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The significance of precursor status for mature T-cell neoplasms has not been elucidated. Diagnosis of T-cell neoplasms is often challenging and sometimes overlooked when leukocytosis is not evident and neoplastic cell morphology is hardly distinguishable. Here, we report two cases of monoclonal T lymphocytosis (MTL) without evident lymphocytosis and lymphadenopathies that show slightly diminished CD5 and/or CD7 surface antigens as the first clue of diagnosis. Recently, some reports have demonstrated the possibility that monoclonal lymphocytosis precedes leukemia/lymphoma. Although its clinical significance is unknown, flow cytometric analysis of peripheral blood is useful for detection of occult MTL and careful follow-up is required.

Original languageEnglish (US)
Pages (from-to)785-787
Number of pages3
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume53
Issue number8
StatePublished - Jan 1 2012

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CD7 Antigens
Lymphocytosis
Surface Antigens
T-Lymphocytes
Leukocytosis
Lymphoma
Neoplasms
Leukemia

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kawano, Hiroki ; Minagawa, Kentaro ; Wakahashi, Kanako ; Kawano, Yuko ; Sada, Akiko ; Matsui, Toshimitsu ; Katayama, Yoshio. / [Diminished expression of CD5 and/or CD7 surface antigens as the first clue of diagnosis for monoclonal T lymphocytosis]. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 2012 ; Vol. 53, No. 8. pp. 785-787.
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[Diminished expression of CD5 and/or CD7 surface antigens as the first clue of diagnosis for monoclonal T lymphocytosis]. / Kawano, Hiroki; Minagawa, Kentaro; Wakahashi, Kanako; Kawano, Yuko; Sada, Akiko; Matsui, Toshimitsu; Katayama, Yoshio.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 53, No. 8, 01.01.2012, p. 785-787.

Research output: Contribution to journalArticle

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AU - Kawano, Hiroki

AU - Minagawa, Kentaro

AU - Wakahashi, Kanako

AU - Kawano, Yuko

AU - Sada, Akiko

AU - Matsui, Toshimitsu

AU - Katayama, Yoshio

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AB - The significance of precursor status for mature T-cell neoplasms has not been elucidated. Diagnosis of T-cell neoplasms is often challenging and sometimes overlooked when leukocytosis is not evident and neoplastic cell morphology is hardly distinguishable. Here, we report two cases of monoclonal T lymphocytosis (MTL) without evident lymphocytosis and lymphadenopathies that show slightly diminished CD5 and/or CD7 surface antigens as the first clue of diagnosis. Recently, some reports have demonstrated the possibility that monoclonal lymphocytosis precedes leukemia/lymphoma. Although its clinical significance is unknown, flow cytometric analysis of peripheral blood is useful for detection of occult MTL and careful follow-up is required.

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