[Diminished expression of CD5 and/or CD7 surface antigens as the first clue of diagnosis for monoclonal T lymphocytosis].

Hiroki Kawano, Kentaro Minagawa, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Toshimitsu Matsui, Yoshio Katayama

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The significance of precursor status for mature T-cell neoplasms has not been elucidated. Diagnosis of T-cell neoplasms is often challenging and sometimes overlooked when leukocytosis is not evident and neoplastic cell morphology is hardly distinguishable. Here, we report two cases of monoclonal T lymphocytosis (MTL) without evident lymphocytosis and lymphadenopathies that show slightly diminished CD5 and/or CD7 surface antigens as the first clue of diagnosis. Recently, some reports have demonstrated the possibility that monoclonal lymphocytosis precedes leukemia/lymphoma. Although its clinical significance is unknown, flow cytometric analysis of peripheral blood is useful for detection of occult MTL and careful follow-up is required.

Original languageEnglish (US)
Pages (from-to)785-787
Number of pages3
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume53
Issue number8
StatePublished - Aug 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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