DIPSPADES: Assembler for highly polymorphic diploid genomes

Yana Safonova, Anton Bankevich, Pavel A. Pevzner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

While the number of sequenced diploid genomes of interest have been steadily increasing in the last few years, assembly of highly polymorphic (HP) diploid genomes remains challenging. As a result, there is shortage of tools for assembling HP genomes from NGS data. The initial approaches to assembling HP genomes were proposed in the pre-NGS era and are not well suited for NGS projects. We present the first de Bruijn graph assembler dipSPAdes for HP genomes and demonstrate that it significantly improves on the state-of-the-art in the HP genome assembly.

Original languageEnglish (US)
Title of host publicationResearch in Computational Molecular Biology - 18th Annual International Conference, RECOMB 2014, Proceedings
PublisherSpringer Verlag
Pages265-279
Number of pages15
ISBN (Print)9783319052687
DOIs
StatePublished - 2014
Event18th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2014 - Pittsburgh, PA, United States
Duration: Apr 2 2014Apr 5 2014

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8394 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other18th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2014
Country/TerritoryUnited States
CityPittsburgh, PA
Period4/2/144/5/14

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

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