Direct generation of oxygen-stabilized radicals by H• transfer from transition metal hydrides

Jonathan L. Kuo, John Hartung, Arthur Han, Jack R. Norton

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Transition-metal hydrides generate α-alkoxy radicals by H• transfer to enol ethers. We have measured the rate constant for transfer from CpCr-(CO)3H to n-butyl vinyl ether and have examined the chemistry of radicals generated by such transfers. Radicals from appropriate substrates undergo 5-exo cyclization, with higher diastereoselectivity than the analogous allcarbon radicals. From such radicals it is straightforward to make substituted tetrahydrofurans.

Original languageEnglish (US)
Pages (from-to)1036-1039
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number3
DOIs
StatePublished - Jan 28 2015

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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