Direct inhibiton of tyrosine hydroxylase activity by catechol estrogens

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Catechol estrogens, the 2-hydroxylated metabolites of estrogens, recently shown to be formed in brain, inhibit tyrosine hydroxylase, the enzyme that catalyzes the pivotal step in the biosynthesis of the neurotransmitters dopamine and norepinephrine. The nature of the inhibition is by competition with the pterin cofactor and thus resembles feedback inhibition of the enzyme by catecholamines.

Original languageEnglish (US)
Pages (from-to)4841-4843
Number of pages3
JournalJournal of Biological Chemistry
Volume253
Issue number14
StatePublished - Jan 1 1978

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Catechol Estrogens
Tyrosine 3-Monooxygenase
Pterins
Biosynthesis
Enzymes
Metabolites
Catecholamines
Neurotransmitter Agents
Dopamine
Brain
Norepinephrine
Estrogens
Feedback

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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title = "Direct inhibiton of tyrosine hydroxylase activity by catechol estrogens",
abstract = "Catechol estrogens, the 2-hydroxylated metabolites of estrogens, recently shown to be formed in brain, inhibit tyrosine hydroxylase, the enzyme that catalyzes the pivotal step in the biosynthesis of the neurotransmitters dopamine and norepinephrine. The nature of the inhibition is by competition with the pterin cofactor and thus resembles feedback inhibition of the enzyme by catecholamines.",
author = "Thomas Lloyd and Judith Weisz",
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Direct inhibiton of tyrosine hydroxylase activity by catechol estrogens. / Lloyd, Thomas; Weisz, Judith.

In: Journal of Biological Chemistry, Vol. 253, No. 14, 01.01.1978, p. 4841-4843.

Research output: Contribution to journalArticle

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