Direct magnetic resonance imaging of histological tissue samples at 3.0T

Mark D. Meadowcroft, Shutong Zhang, Wanzhan Liu, Sik Park Bu, James R. Connor, Christopher M. Collins, Michael B. Smith, Qing X. Yang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Direct imaging of a histological slice is challenging. The vast difference in dimension between planar size and the thickness of histology slices would require an RF coil to produce a uniform RF magnetic (B1) field in a 2D plane with minimal thickness. In this work a novel RF coil designed specifically for imaging a histology slice was developed and tested. The experimental data demonstrate that the coil is highly sensitive and capable of producing a uniform B1 field distribution in a planar region of histological slides, allowing for the acquisition of high-resolution T 2 images and T2 maps from a 60-μm-thick histological sample. The image intensity and T2 distributions were directly compared with histological staining of the relative iron concentration of the same slice. This work demonstrates the feasibility of using a microimaging histological coil to image thin slices of pathologically diseased tissue to obtain a precise one-to-one comparison between stained tissue and MR images.

Original languageEnglish (US)
Pages (from-to)835-841
Number of pages7
JournalMagnetic Resonance in Medicine
Volume57
Issue number5
DOIs
StatePublished - May 1 2007

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Histology
Magnetic Resonance Imaging
Magnetic Fields
Iron
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Meadowcroft, Mark D. ; Zhang, Shutong ; Liu, Wanzhan ; Bu, Sik Park ; Connor, James R. ; Collins, Christopher M. ; Smith, Michael B. ; Yang, Qing X. / Direct magnetic resonance imaging of histological tissue samples at 3.0T. In: Magnetic Resonance in Medicine. 2007 ; Vol. 57, No. 5. pp. 835-841.
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Meadowcroft, MD, Zhang, S, Liu, W, Bu, SP, Connor, JR, Collins, CM, Smith, MB & Yang, QX 2007, 'Direct magnetic resonance imaging of histological tissue samples at 3.0T', Magnetic Resonance in Medicine, vol. 57, no. 5, pp. 835-841. https://doi.org/10.1002/mrm.21213

Direct magnetic resonance imaging of histological tissue samples at 3.0T. / Meadowcroft, Mark D.; Zhang, Shutong; Liu, Wanzhan; Bu, Sik Park; Connor, James R.; Collins, Christopher M.; Smith, Michael B.; Yang, Qing X.

In: Magnetic Resonance in Medicine, Vol. 57, No. 5, 01.05.2007, p. 835-841.

Research output: Contribution to journalArticle

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