@article{2c7f8c083d95456c854508d82b8d0b60,
title = "Direct regulation of ion channels by fatty acids",
abstract = "A variety of fatty acids regulate the activity of specific ion channels by mechanisms not involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites. Furthermore, these actions of fatty acids occur in patches of membrane excised from the cell and are not mediated by cellular signal transduction pathways that require soluble factors such as nucleotides and calcium. Thus, fatty acids themselves appear to regulate the action of channels directly, much as they regulate the action of several purified enzymes, and might constitute a new class of first or second messengers acting on ion channels.",
author = "Ordway, {Richard W.} and Singer, {Joshua J.} and Walsh, {John V.}",
note = "Funding Information: Acknowledgements Ca 2+ channels are inhibited. These effects would tend The work of the to decrease the amplitude and duration of action authors is supported potentials and/or hyperpolarize the membrane, and by the NSF (DCB thereby inhibit excitation. In this way fatty acids might 8819750) and the function as endogenous counterparts to K + channel NIH (DK 31620). We opener 6° and Ca z+ channel antagonist 22 drugs that Melchior for helpful thank Dr Donald promote relaxation in smooth muscle. discussions and In addition to their direct effects on purified suggestions. to regulate a variety of cell processes ~5'26'3°'48'61-65, proteins and ion channels, fatty acids have been found",
year = "1991",
month = mar,
doi = "10.1016/0166-2236(91)90069-7",
language = "English (US)",
volume = "14",
pages = "96--100",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "3",
}