Direct regulation of ion channels by fatty acids

Richard W. Ordway, Joshua J. Singer, John V. Walsh

Research output: Contribution to journalReview articlepeer-review

336 Scopus citations

Abstract

A variety of fatty acids regulate the activity of specific ion channels by mechanisms not involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites. Furthermore, these actions of fatty acids occur in patches of membrane excised from the cell and are not mediated by cellular signal transduction pathways that require soluble factors such as nucleotides and calcium. Thus, fatty acids themselves appear to regulate the action of channels directly, much as they regulate the action of several purified enzymes, and might constitute a new class of first or second messengers acting on ion channels.

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalTrends in Neurosciences
Volume14
Issue number3
DOIs
StatePublished - Mar 1991

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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