Direct visualization and profiling of protein misfolding and aggregation in live cells

Sicheng Tang, Wenting Wang, Xin Zhang

Research output: Contribution to journalReview articlepeer-review

Abstract

Over the past few years, research tools have been developed to monitor the multistep protein aggregation process in live cells, a process that has been associated with a growing number of human diseases. Herein, we describe recent advances in methods that can either survey the distribution of aggregation at the level of the cellular proteome using mass spectroscopy or discern the multistep aggregation process of specific proteins of interest via fluorescence signals. Future development and application of such technologies are expected to provide insights on mechanisms, diagnosis, and treatment of diseases rooted in protein aggregation.

Original languageEnglish (US)
Pages (from-to)116-123
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume64
DOIs
StatePublished - Oct 2021

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry

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