Directing Mesenchymal Stem Cells with Gold Nanowire Arrays

Qihui Zhou, Zhiyuan Zhao, Ziwei Zhou, Gang Zhang, Ryan C. Chiechi, Patrick van Rijn

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Controlling cell organization is still a major bottleneck in biointerface engineering when the material dimensions decrease to the nanoscale. Here, Au nanowire-patterned array platforms with multiscale design from the macroscale to the nanoscale are developed for studying human bone marrow–derived mesenchymal stem cell (hBM-MSC) response. When the angle of the Au nanowires on glass is increased from 0° to 90°, hBM-MSC arrangement exhibits a transition from a unidirectional distribution induced by a vector response to a bimodal polarization pattern. The degree of cell vector response and elongation decreases with increasing nanowire angles from 0° to 90°. Further, it is demonstrated that the specific cell adhesion and organization are dependent on the surface micro/nanotopography, which is greatly enhanced by introducing stem cell-material affinity differences. An ideal model and new insights into a deeper understanding of cell–nano-biointerface interactions are provided.

Original languageEnglish (US)
Article number1800334
JournalAdvanced Materials Interfaces
Volume5
Issue number14
DOIs
StatePublished - Jul 23 2018

All Science Journal Classification (ASJC) codes

  • Mechanics of Materials
  • Mechanical Engineering

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