Directing Mesenchymal Stem Cells with Gold Nanowire Arrays

Qihui Zhou, Zhiyuan Zhao, Ziwei Zhou, Gang Zhang, Ryan C. Chiechi, Patrick van Rijn

Research output: Contribution to journalArticle

Abstract

Controlling cell organization is still a major bottleneck in biointerface engineering when the material dimensions decrease to the nanoscale. Here, Au nanowire-patterned array platforms with multiscale design from the macroscale to the nanoscale are developed for studying human bone marrow–derived mesenchymal stem cell (hBM-MSC) response. When the angle of the Au nanowires on glass is increased from 0° to 90°, hBM-MSC arrangement exhibits a transition from a unidirectional distribution induced by a vector response to a bimodal polarization pattern. The degree of cell vector response and elongation decreases with increasing nanowire angles from 0° to 90°. Further, it is demonstrated that the specific cell adhesion and organization are dependent on the surface micro/nanotopography, which is greatly enhanced by introducing stem cell-material affinity differences. An ideal model and new insights into a deeper understanding of cell–nano-biointerface interactions are provided.

Original languageEnglish (US)
Article number1800334
JournalAdvanced Materials Interfaces
Volume5
Issue number14
DOIs
StatePublished - Jul 23 2018

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Stem cells
Nanowires
Gold
Bone
Cell adhesion
Elongation
Polarization
Glass

All Science Journal Classification (ASJC) codes

  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Zhou, Q., Zhao, Z., Zhou, Z., Zhang, G., Chiechi, R. C., & van Rijn, P. (2018). Directing Mesenchymal Stem Cells with Gold Nanowire Arrays. Advanced Materials Interfaces, 5(14), [1800334]. https://doi.org/10.1002/admi.201800334
Zhou, Qihui ; Zhao, Zhiyuan ; Zhou, Ziwei ; Zhang, Gang ; Chiechi, Ryan C. ; van Rijn, Patrick. / Directing Mesenchymal Stem Cells with Gold Nanowire Arrays. In: Advanced Materials Interfaces. 2018 ; Vol. 5, No. 14.
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Zhou, Q, Zhao, Z, Zhou, Z, Zhang, G, Chiechi, RC & van Rijn, P 2018, 'Directing Mesenchymal Stem Cells with Gold Nanowire Arrays', Advanced Materials Interfaces, vol. 5, no. 14, 1800334. https://doi.org/10.1002/admi.201800334

Directing Mesenchymal Stem Cells with Gold Nanowire Arrays. / Zhou, Qihui; Zhao, Zhiyuan; Zhou, Ziwei; Zhang, Gang; Chiechi, Ryan C.; van Rijn, Patrick.

In: Advanced Materials Interfaces, Vol. 5, No. 14, 1800334, 23.07.2018.

Research output: Contribution to journalArticle

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Zhou Q, Zhao Z, Zhou Z, Zhang G, Chiechi RC, van Rijn P. Directing Mesenchymal Stem Cells with Gold Nanowire Arrays. Advanced Materials Interfaces. 2018 Jul 23;5(14). 1800334. https://doi.org/10.1002/admi.201800334