Discrete dynamic modeling of signal transduction networks

Assieh Saadatpour, Réka Albert

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

Newly available experimental data characterizing different processes involved in signaling pathways have provided the opportunity for network analysis and modeling of these interacting pathways. Current approaches in studying the dynamics of signaling networks fall into two major groups, namely, continuous and discrete models. The lack of kinetic information for biochemical interactions has limited the wide applicability of continuous models. To address this issue, discrete dynamic models, based on a qualitative description of a system’s variables, have been applied for the analysis of biological systems withmany unknown parameters. The purpose of this chapter is to give a detailed description of Booleanmodeling, the simplest type of discrete dynamic modeling, and the ways in which it can be applied to analyze the dynamics of signaling networks. This is followed by practical examples of a Boolean dynamic framework applied to the modeling of the abscisic acid signal transduction network in plants as well as theT-cell survival signaling network in humans.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages255-272
Number of pages18
DOIs
StatePublished - Jan 1 2012

Publication series

NameMethods in Molecular Biology
Volume880
ISSN (Print)1064-3745

Fingerprint

Abscisic Acid
Systems Analysis
Signal Transduction
Cell Survival

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

Saadatpour, A., & Albert, R. (2012). Discrete dynamic modeling of signal transduction networks. In Methods in Molecular Biology (pp. 255-272). (Methods in Molecular Biology; Vol. 880). Humana Press Inc.. https://doi.org/10.1007/978-1-61779-833-7_12
Saadatpour, Assieh ; Albert, Réka. / Discrete dynamic modeling of signal transduction networks. Methods in Molecular Biology. Humana Press Inc., 2012. pp. 255-272 (Methods in Molecular Biology).
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Saadatpour, A & Albert, R 2012, Discrete dynamic modeling of signal transduction networks. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 880, Humana Press Inc., pp. 255-272. https://doi.org/10.1007/978-1-61779-833-7_12

Discrete dynamic modeling of signal transduction networks. / Saadatpour, Assieh; Albert, Réka.

Methods in Molecular Biology. Humana Press Inc., 2012. p. 255-272 (Methods in Molecular Biology; Vol. 880).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Saadatpour A, Albert R. Discrete dynamic modeling of signal transduction networks. In Methods in Molecular Biology. Humana Press Inc. 2012. p. 255-272. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-61779-833-7_12