Discrete dynamic network modeling of oncogenic signaling: Mechanistic insights for personalized treatment of cancer

Jorge G.T. Zañudo, Steven N. Steinway, Réka Albert

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Targeted drugs disrupting proteins that are dysregulated in cancer have emerged as promising treatments because of their specificity to cancer cell aberrations and thus their improved side effect profile. However, their success remains limited, largely due to existing or emergent therapy resistance. We suggest that this is due to limited understanding of the entire relevant cellular landscape. A class of mathematical models called discrete dynamic network models can be used to understand the integrated effect of an individual tumor's aberrations. We review the recent literature on discrete dynamic models of cancer and highlight their predicted therapeutic strategies. We believe dynamic network modeling can be used to drive treatment decision-making in a personalized manner to direct improved treatments in cancer.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalCurrent Opinion in Systems Biology
Volume9
DOIs
StatePublished - Jun 2018

All Science Journal Classification (ASJC) codes

  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Drug Discovery
  • Computer Science Applications
  • Applied Mathematics

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