TY - JOUR
T1 - Disease Burden and Attributable Risk Factors of Alzheimer’s Disease and Dementia in China from 1990 to 2019
AU - Li, R.
AU - Qi, J.
AU - Yang, Y.
AU - Wu, Y.
AU - Yin, P.
AU - Zhou, M.
AU - Qian, Z.
AU - LeBaige, M. H.
AU - McMillin, S. E.
AU - Guo, Haoyan
AU - Lin, Hualiang
N1 - Funding Information:
This work was supported by the National key Research and Development program of China [2020YFC2008705].
Funding Information:
Dr Qian reports funding from HRSA, MCH Bureau for the Center of Excellence in Maternal and Child Health Education, Research, and Practice. Dr McMillin reports payment for energy efficiency advocacy consultation from Renew Missouri and funding form Section Chair and Convenor, Social Innovation and Entrepreneurship special interest section of the Society for Social Work and Research. The other authors have nothing to disclose. The funders had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; the preparation, review or approval of the manuscript; or the decision to submit the manuscript for publication. The authors declare no conflicts and competing interests that could have appeared to influence the work reported in this paper.
Publisher Copyright:
© 2022, Serdi and Springer Nature Switzerland AG.
PY - 2022/4
Y1 - 2022/4
N2 - Background: Updated information on the burden of Alzheimer’s disease and other forms of dementia are of great importance for evidence-based health care planning. However, such an estimate has been lacking in Chinese populations at both national and provincial levels. Objective: To estimate the temporal trends and the attributable burdens of selected risk factors of Alzheimer’s disease and other forms of dementia in China. Design, Setting, and Participants: This is an observational description of the Global Burden of Diseases Study 2019 (GBD 2019). Data on incidence, mortality, prevalence, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs) of Alzheimer’s disease and other forms of dementia were derived from the GBD 2019 study at both national and provincial levels in China. Measurements: Six indicators were used: incidence, mortality, prevalence, DALYs, YLLs, and YLDs. Absolute numbers in detail by age, sex, region, and age-standardized rates (with 95% uncertainty intervals) were calculated. Results: There were notable increasing trends in the number of deaths (247.9%), incidence (264.8%), prevalence (296.5%), DALYs (228.1%), YLDs (308.7%) and YLLs (201.7%) from 1990 to 2019, respectively. The corresponding age-standardized rates increased by 6.2%, 19.3%, 33.6%, 10.7%, 33.4% and 3.1%. Smoking, high body mass index, high fasting plasma glucose levels, and metabolic risks were the four leading risk factors. Higher burden was observed among females versus males and in the more developed regions. Conclusions: The disease burden in China were increasing substantially. Regional differences of the disease burden are accompanied by discrepancies of economic level and geographical location, as well as different levels of exposure to risk factors. Targeted prevention and control strategies are urgently needed to reduce the disease burden.
AB - Background: Updated information on the burden of Alzheimer’s disease and other forms of dementia are of great importance for evidence-based health care planning. However, such an estimate has been lacking in Chinese populations at both national and provincial levels. Objective: To estimate the temporal trends and the attributable burdens of selected risk factors of Alzheimer’s disease and other forms of dementia in China. Design, Setting, and Participants: This is an observational description of the Global Burden of Diseases Study 2019 (GBD 2019). Data on incidence, mortality, prevalence, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs) of Alzheimer’s disease and other forms of dementia were derived from the GBD 2019 study at both national and provincial levels in China. Measurements: Six indicators were used: incidence, mortality, prevalence, DALYs, YLLs, and YLDs. Absolute numbers in detail by age, sex, region, and age-standardized rates (with 95% uncertainty intervals) were calculated. Results: There were notable increasing trends in the number of deaths (247.9%), incidence (264.8%), prevalence (296.5%), DALYs (228.1%), YLDs (308.7%) and YLLs (201.7%) from 1990 to 2019, respectively. The corresponding age-standardized rates increased by 6.2%, 19.3%, 33.6%, 10.7%, 33.4% and 3.1%. Smoking, high body mass index, high fasting plasma glucose levels, and metabolic risks were the four leading risk factors. Higher burden was observed among females versus males and in the more developed regions. Conclusions: The disease burden in China were increasing substantially. Regional differences of the disease burden are accompanied by discrepancies of economic level and geographical location, as well as different levels of exposure to risk factors. Targeted prevention and control strategies are urgently needed to reduce the disease burden.
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U2 - 10.14283/jpad.2021.69
DO - 10.14283/jpad.2021.69
M3 - Article
C2 - 35543004
AN - SCOPUS:85123497891
SN - 2274-5807
VL - 9
SP - 306
EP - 314
JO - The journal of prevention of Alzheimer's disease
JF - The journal of prevention of Alzheimer's disease
IS - 2
ER -
