Disparate inclusion of older adults in clinical trials: priorities and opportunities for policy and practice change

Angelica P. Herrera, Shedra Amy Snipes, Denae W. King, Isabel Torres-Vigil, Daniel S. Goldberg, Armin D. Wenberg

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Older adults are vastly underrepresented in clinical trials in spite of shouldering a disproportionate burden of disease and consumption of prescription drugs and therapies, restricting treatments' generalizability, efficacy, and safety. Eliminating Disparities in Clinical Trials, a national initiative comprising a stakeholder network of researchers, community advocates, policymakers, and federal representatives, undertook, a critical analysis of older adults' structural barriers to clinical trial participation. We present practice and policy change recommendations emerging from this process and their rationale, which spanned multiple themes: (1) decision making with cognitively impaired patients; (2) pharmacokinetic differences and physiological age; (3) health literacy, communication, and aging; (4) geriatric training; (5) federal monitoring and accountability; (6) clinical trial costs; and (7) cumulative effects of aging and ethnicity. Chronic Disease Revention and Control Research.

Original languageEnglish (US)
Pages (from-to)S105-S112
JournalAmerican journal of public health
Volume100
Issue numberSUPPL. 1
DOIs
StatePublished - Apr 1 2010

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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