Disparate inclusion of older adults in clinical trials: priorities and opportunities for policy and practice change

Angelica P. Herrera, Shedra Amy Snipes, Denae W. King, Isabel Torres-Vigil, Daniel S. Goldberg, Armin D. Wenberg

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Older adults are vastly underrepresented in clinical trials in spite of shouldering a disproportionate burden of disease and consumption of prescription drugs and therapies, restricting treatments' generalizability, efficacy, and safety. Eliminating Disparities in Clinical Trials, a national initiative comprising a stakeholder network of researchers, community advocates, policymakers, and federal representatives, undertook, a critical analysis of older adults' structural barriers to clinical trial participation. We present practice and policy change recommendations emerging from this process and their rationale, which spanned multiple themes: (1) decision making with cognitively impaired patients; (2) pharmacokinetic differences and physiological age; (3) health literacy, communication, and aging; (4) geriatric training; (5) federal monitoring and accountability; (6) clinical trial costs; and (7) cumulative effects of aging and ethnicity. Chronic Disease Revention and Control Research.

Original languageEnglish (US)
JournalAmerican journal of public health
Volume100
Issue numberSUPPL. 1
DOIs
StatePublished - Apr 1 2010

Fingerprint

Clinical Trials
Health Communication
Health Literacy
Prescription Drugs
Social Responsibility
Geriatrics
Decision Making
Chronic Disease
Pharmacokinetics
Research Personnel
Safety
Costs and Cost Analysis
Drug Therapy
Research

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Herrera, Angelica P. ; Snipes, Shedra Amy ; King, Denae W. ; Torres-Vigil, Isabel ; Goldberg, Daniel S. ; Wenberg, Armin D. / Disparate inclusion of older adults in clinical trials : priorities and opportunities for policy and practice change. In: American journal of public health. 2010 ; Vol. 100, No. SUPPL. 1.
@article{1cbd737e0459459c85b51cf867095c89,
title = "Disparate inclusion of older adults in clinical trials: priorities and opportunities for policy and practice change",
abstract = "Older adults are vastly underrepresented in clinical trials in spite of shouldering a disproportionate burden of disease and consumption of prescription drugs and therapies, restricting treatments' generalizability, efficacy, and safety. Eliminating Disparities in Clinical Trials, a national initiative comprising a stakeholder network of researchers, community advocates, policymakers, and federal representatives, undertook, a critical analysis of older adults' structural barriers to clinical trial participation. We present practice and policy change recommendations emerging from this process and their rationale, which spanned multiple themes: (1) decision making with cognitively impaired patients; (2) pharmacokinetic differences and physiological age; (3) health literacy, communication, and aging; (4) geriatric training; (5) federal monitoring and accountability; (6) clinical trial costs; and (7) cumulative effects of aging and ethnicity. Chronic Disease Revention and Control Research.",
author = "Herrera, {Angelica P.} and Snipes, {Shedra Amy} and King, {Denae W.} and Isabel Torres-Vigil and Goldberg, {Daniel S.} and Wenberg, {Armin D.}",
year = "2010",
month = "4",
day = "1",
doi = "10.2105/AJPH.2009.162982",
language = "English (US)",
volume = "100",
journal = "American Journal of Public Health",
issn = "0090-0036",
publisher = "American Public Health Association Inc.",
number = "SUPPL. 1",

}

Disparate inclusion of older adults in clinical trials : priorities and opportunities for policy and practice change. / Herrera, Angelica P.; Snipes, Shedra Amy; King, Denae W.; Torres-Vigil, Isabel; Goldberg, Daniel S.; Wenberg, Armin D.

In: American journal of public health, Vol. 100, No. SUPPL. 1, 01.04.2010.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Disparate inclusion of older adults in clinical trials

T2 - priorities and opportunities for policy and practice change

AU - Herrera, Angelica P.

AU - Snipes, Shedra Amy

AU - King, Denae W.

AU - Torres-Vigil, Isabel

AU - Goldberg, Daniel S.

AU - Wenberg, Armin D.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Older adults are vastly underrepresented in clinical trials in spite of shouldering a disproportionate burden of disease and consumption of prescription drugs and therapies, restricting treatments' generalizability, efficacy, and safety. Eliminating Disparities in Clinical Trials, a national initiative comprising a stakeholder network of researchers, community advocates, policymakers, and federal representatives, undertook, a critical analysis of older adults' structural barriers to clinical trial participation. We present practice and policy change recommendations emerging from this process and their rationale, which spanned multiple themes: (1) decision making with cognitively impaired patients; (2) pharmacokinetic differences and physiological age; (3) health literacy, communication, and aging; (4) geriatric training; (5) federal monitoring and accountability; (6) clinical trial costs; and (7) cumulative effects of aging and ethnicity. Chronic Disease Revention and Control Research.

AB - Older adults are vastly underrepresented in clinical trials in spite of shouldering a disproportionate burden of disease and consumption of prescription drugs and therapies, restricting treatments' generalizability, efficacy, and safety. Eliminating Disparities in Clinical Trials, a national initiative comprising a stakeholder network of researchers, community advocates, policymakers, and federal representatives, undertook, a critical analysis of older adults' structural barriers to clinical trial participation. We present practice and policy change recommendations emerging from this process and their rationale, which spanned multiple themes: (1) decision making with cognitively impaired patients; (2) pharmacokinetic differences and physiological age; (3) health literacy, communication, and aging; (4) geriatric training; (5) federal monitoring and accountability; (6) clinical trial costs; and (7) cumulative effects of aging and ethnicity. Chronic Disease Revention and Control Research.

UR - http://www.scopus.com/inward/record.url?scp=77950591512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950591512&partnerID=8YFLogxK

U2 - 10.2105/AJPH.2009.162982

DO - 10.2105/AJPH.2009.162982

M3 - Article

C2 - 20147682

AN - SCOPUS:77950591512

VL - 100

JO - American Journal of Public Health

JF - American Journal of Public Health

SN - 0090-0036

IS - SUPPL. 1

ER -