Disposition of T-2 Toxin, a Trichothecene Mycotoxin, in Intravascularly Dosed Swine

Richard A. Corley, Steven P. Swanson, Gregory J. Gullo, Louis Johnson, Val Richard Beasley, William B. Buck

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Metabolite profiles in plasma and tissues of two swine were determined following intravascular administration of tritium-labeled T-2 toxin. The plasma elimination phase half-life was 90 min for total tritium residues. At 4-h postdosing (time of death), the greatest amount of radioactivity was located in the gastrointestinal tract (15.5 and 24.1% of the dose for the two swine). The remaining tissues accounted for 5.2 and 4.7% of the dose for the two swine. A total of 21 metabolites was identified by reversed-phase HPLC radiochromatography. Approximately 55% of the extractable radioactivity in the tissues and gastrointestinal tract of both swine corresponded to T-2 toxin, HT-2, deepoxy HT-2, T-2 triol, deepoxy T-2 triol, 3’-OH T-2, 3’-OH HT-2, T-2 tetraol, and deepoxy T-2 tetraol. The major metabolite in tissues, PM-XV, did not correspond to any standard and represented an additional 27% of the extractable radioactivity.

Original languageEnglish (US)
Pages (from-to)868-875
Number of pages8
JournalJournal of agricultural and food chemistry
Volume34
Issue number5
DOIs
StatePublished - Jan 1 1986

Fingerprint

T-2 Toxin
Trichothecenes
T-2 toxin
trichothecenes
Mycotoxins
mycotoxins
Radioactivity
Swine
Metabolites
Tissue
swine
tritium
Tritium
metabolites
gastrointestinal system
Gastrointestinal Tract
Plasmas
reversed-phase high performance liquid chromatography
dosage
half life

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Cite this

Corley, Richard A. ; Swanson, Steven P. ; Gullo, Gregory J. ; Johnson, Louis ; Beasley, Val Richard ; Buck, William B. / Disposition of T-2 Toxin, a Trichothecene Mycotoxin, in Intravascularly Dosed Swine. In: Journal of agricultural and food chemistry. 1986 ; Vol. 34, No. 5. pp. 868-875.
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Disposition of T-2 Toxin, a Trichothecene Mycotoxin, in Intravascularly Dosed Swine. / Corley, Richard A.; Swanson, Steven P.; Gullo, Gregory J.; Johnson, Louis; Beasley, Val Richard; Buck, William B.

In: Journal of agricultural and food chemistry, Vol. 34, No. 5, 01.01.1986, p. 868-875.

Research output: Contribution to journalArticle

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AU - Buck, William B.

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