TY - JOUR
T1 - Disruption in Th1/Th2 immune response in young adult smokers
AU - Whetzel, Courtney A.
AU - Corwin, Elizabeth J.
AU - Klein, Laura Cousino
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/1
Y1 - 2007/1
N2 - Interferon (IFN)-γ and IL-10 cytokines, measures of Th1 and Th2 immunity, were examined in 20 healthy nonsmokers (12 males, 8 females) and 19 smokers (11 males, 8 females), aged 19-41 years (23.46 ± 0.82 years). Nonsmokers came to the laboratory once; smokers came to the laboratory after ad lib smoking and following 24-h smoking abstinence. Salivary cotinine and expired CO confirmed smoking status. Plasma was collected at the end of each lab session and assayed for peripheral IFN-γ and IL-10 levels. Among smokers, peripheral IFN-γ, IL-10, or IFN-γ/IL-10 ratio levels did not change in response to 24-h smoking abstinence. IFN-γ levels and IFN-γ/IL-10 ratios were higher among female smokers while smoking and following 24-h abstinence compared to male smokers in both conditions and compared to male and female nonsmokers. There was no sex or smoking status difference in IL-10 levels. Results suggest that cigarette smoking may have at least short-term damaging effects on the body's normal immune balance, particularly for women.
AB - Interferon (IFN)-γ and IL-10 cytokines, measures of Th1 and Th2 immunity, were examined in 20 healthy nonsmokers (12 males, 8 females) and 19 smokers (11 males, 8 females), aged 19-41 years (23.46 ± 0.82 years). Nonsmokers came to the laboratory once; smokers came to the laboratory after ad lib smoking and following 24-h smoking abstinence. Salivary cotinine and expired CO confirmed smoking status. Plasma was collected at the end of each lab session and assayed for peripheral IFN-γ and IL-10 levels. Among smokers, peripheral IFN-γ, IL-10, or IFN-γ/IL-10 ratio levels did not change in response to 24-h smoking abstinence. IFN-γ levels and IFN-γ/IL-10 ratios were higher among female smokers while smoking and following 24-h abstinence compared to male smokers in both conditions and compared to male and female nonsmokers. There was no sex or smoking status difference in IL-10 levels. Results suggest that cigarette smoking may have at least short-term damaging effects on the body's normal immune balance, particularly for women.
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U2 - 10.1016/j.addbeh.2006.03.007
DO - 10.1016/j.addbeh.2006.03.007
M3 - Article
C2 - 16644136
AN - SCOPUS:33750814420
VL - 32
SP - 1
EP - 8
JO - Addictive Behaviors
JF - Addictive Behaviors
SN - 0306-4603
IS - 1
ER -