Abstract
Interferon (IFN)-γ and IL-10 cytokines, measures of Th1 and Th2 immunity, were examined in 20 healthy nonsmokers (12 males, 8 females) and 19 smokers (11 males, 8 females), aged 19-41 years (23.46 ± 0.82 years). Nonsmokers came to the laboratory once; smokers came to the laboratory after ad lib smoking and following 24-h smoking abstinence. Salivary cotinine and expired CO confirmed smoking status. Plasma was collected at the end of each lab session and assayed for peripheral IFN-γ and IL-10 levels. Among smokers, peripheral IFN-γ, IL-10, or IFN-γ/IL-10 ratio levels did not change in response to 24-h smoking abstinence. IFN-γ levels and IFN-γ/IL-10 ratios were higher among female smokers while smoking and following 24-h abstinence compared to male smokers in both conditions and compared to male and female nonsmokers. There was no sex or smoking status difference in IL-10 levels. Results suggest that cigarette smoking may have at least short-term damaging effects on the body's normal immune balance, particularly for women.
Original language | English (US) |
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Pages (from-to) | 1-8 |
Number of pages | 8 |
Journal | Addictive Behaviors |
Volume | 32 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2007 |
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Clinical Psychology
- Toxicology
- Psychiatry and Mental health