Disseminating melanoma cells surf on calcium waves

Jianwei Sun, Shengchen Lin, Tyler Keeley, Shengyu Yang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study, we investigated the mechanism underlying calcium-mediated invasion and metastasis in melanoma and discovered that hyperactive Ca2+ oscillation in melanoma cells enhanced invasion and metastasis by promoting invadopodium formation and extracellular matrix remodeling.

Original languageEnglish (US)
Article numbere1002714
JournalMolecular and Cellular Oncology
Volume2
Issue number4
DOIs
StatePublished - Oct 2 2015

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

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