Disseminating melanoma cells surf on calcium waves

Jianwei Sun, Shengchen Lin, Tyler Keeley, Shengyu Yang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study, we investigated the mechanism underlying calcium-mediated invasion and metastasis in melanoma and discovered that hyperactive Ca2+ oscillation in melanoma cells enhanced invasion and metastasis by promoting invadopodium formation and extracellular matrix remodeling.

Original languageEnglish (US)
Article numbere1002714
JournalMolecular and Cellular Oncology
Volume2
Issue number4
DOIs
StatePublished - Oct 2 2015

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Calcium Signaling
Melanoma
Neoplasm Metastasis
Extracellular Matrix
Calcium
Neoplasms
Podosomes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

Cite this

Sun, Jianwei ; Lin, Shengchen ; Keeley, Tyler ; Yang, Shengyu. / Disseminating melanoma cells surf on calcium waves. In: Molecular and Cellular Oncology. 2015 ; Vol. 2, No. 4.
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Disseminating melanoma cells surf on calcium waves. / Sun, Jianwei; Lin, Shengchen; Keeley, Tyler; Yang, Shengyu.

In: Molecular and Cellular Oncology, Vol. 2, No. 4, e1002714, 02.10.2015.

Research output: Contribution to journalArticle

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