Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study, we investigated the mechanism underlying calcium-mediated invasion and metastasis in melanoma and discovered that hyperactive Ca2+ oscillation in melanoma cells enhanced invasion and metastasis by promoting invadopodium formation and extracellular matrix remodeling.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Cancer Research