Distinct Deletions of Chromosome 9p Associated with Melanoma versus Glioma, Lung Cancer, and Leukemia

Aaron Coleman, Gavin Robertson, Tracy G. Lugo

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Deletions of DNA on chromosome 9p21-22 are frequently observed in cells derived from melanomas, gliomas, non-small cell lung cancers, and acute lymphoblastic leukemia. The minimal deletion shared by the latter three cancers extends from the interferon-a locus towards the centromere; its centromeric end is flanked by the gene encoding methylthioadenosine phosphorylase. We have determined that the telomeric end of the minimal homozygous deletion shared by two melanoma cell lines does not include the methylthioadenosine phosphorylase locus. Thus, a distinct region of DNA is lost in melanoma. The physical size of this region remains to be defined precisely, but it may extend over several million base pairs.

Original languageEnglish (US)
Pages (from-to)344-348
Number of pages5
JournalCancer Research
Volume54
Issue number2
StatePublished - Jan 1 1994

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Chromosome Deletion
Glioma
Melanoma
Lung Neoplasms
Leukemia
Chromosomes, Human, Pair 22
Centromere
DNA
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Non-Small Cell Lung Carcinoma
Base Pairing
Interferons
Cell Line
Genes
Neoplasms
5'-methylthioadenosine phosphorylase

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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abstract = "Deletions of DNA on chromosome 9p21-22 are frequently observed in cells derived from melanomas, gliomas, non-small cell lung cancers, and acute lymphoblastic leukemia. The minimal deletion shared by the latter three cancers extends from the interferon-a locus towards the centromere; its centromeric end is flanked by the gene encoding methylthioadenosine phosphorylase. We have determined that the telomeric end of the minimal homozygous deletion shared by two melanoma cell lines does not include the methylthioadenosine phosphorylase locus. Thus, a distinct region of DNA is lost in melanoma. The physical size of this region remains to be defined precisely, but it may extend over several million base pairs.",
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Distinct Deletions of Chromosome 9p Associated with Melanoma versus Glioma, Lung Cancer, and Leukemia. / Coleman, Aaron; Robertson, Gavin; Lugo, Tracy G.

In: Cancer Research, Vol. 54, No. 2, 01.01.1994, p. 344-348.

Research output: Contribution to journalArticle

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