Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism

Reyad A. Elbarbary, Lynne E. Maquat

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Two new studies show that RNA-binding proteins can mediate distinct and beneficial effects to cells by binding to the extensive double-stranded RNA (dsRNA) structures of inverted-repeat Alu elements (IRAlus). One study reports stress-induced export of the 110-kDa isoform of the adenosine deaminase acting on RNA 1 protein (ADAR1p110) to the cytoplasm, where it binds IRAlus so as to protect many mRNAs encoding anti-apoptotic proteins from degradation. The other study demonstrates that binding of the nuclear helicase DHX9 to IRAlus embedded within RNAs minimizes defects in RNA processing.

Original languageEnglish (US)
Pages (from-to)496-498
Number of pages3
JournalNature Structural and Molecular Biology
Volume24
Issue number6
DOIs
StatePublished - Jun 6 2017

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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