In this paper, we study distributed big-data non-convex optimization in multi-Agent networks. We consider the (constrained) minimization of the sum of a smooth (possibly) nonconvex function, i.e., the agents' sum-utility, plus a convex (possibly) nonsmooth regularizer. Our interest is in big-data problems wherein there is a large number of variables to optimize. If treated by means of standard distributed optimization algorithms, these large-scale problems may be intractable, due to the prohibitive local computation and communication burden at each node. We propose a novel distributed solution method whereby at each iteration agents optimize and then communicate (in an uncoordinated fashion) only a subset of their decision variables. To deal with non-convexity of the cost function, the novel scheme hinges on Successive Convex Approximation (SCA) techniques coupled with i) a tracking mechanism instrumental to locally estimate gradient averages; and ii) a novel block-wise consensus-based protocol to perform local block-Averaging operations and gradient tacking. Asymptotic convergence to stationary solutions of the nonconvex problem is established. Finally, numerical results show the effectiveness of the proposed algorithm and highlight how the block dimension impacts on the communication overhead and practical convergence speed.