Distributed open-loop optogenetic control of cortical epileptiform activity in a Wilson-Cowan network

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a distributed open-loop optogenetic control for suppression of epileptiform activity in a neural population model of cortex. In epilepsy, cortical seizures or epileptiform activities occur when pyramidal cells become hyper-excitable due to the loss of inhibitory interneurons. A straightforward way to suppress these epileptiform activities is to inhibit pyramidal cells by exciting interneurons. Thus, in this paper, the inhibitory neural population is targeted for the application of open-loop optogenetic control. By introducing computational model of the light-gated Channelrhodopsin-2 (ChR2) ion channels into the well-known Wilson-Cowan model, we first establish a neural population model for optogenetic control of cortical dynamics. Then, we investigate the effects of open-loop optogenetic control parameters (irradiance intensity and pulse duration) on the control performance. Finally, we use a spatially distributed control strategy to normalize cortical dynamics with minimum optical stimulations. The simulation results demonstrate the effectiveness of our propose control method for suppression of epileptiform activities.

Original languageEnglish (US)
Title of host publication8th International IEEE EMBS Conference on Neural Engineering, NER 2017
PublisherIEEE Computer Society
Pages469-472
Number of pages4
ISBN (Electronic)9781538619162
DOIs
StatePublished - Aug 10 2017
Event8th International IEEE EMBS Conference on Neural Engineering, NER 2017 - Shanghai, China
Duration: May 25 2017May 28 2017

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Other

Other8th International IEEE EMBS Conference on Neural Engineering, NER 2017
CountryChina
CityShanghai
Period5/25/175/28/17

Fingerprint

Ions

All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Mechanical Engineering

Cite this

Che, Y. (2017). Distributed open-loop optogenetic control of cortical epileptiform activity in a Wilson-Cowan network. In 8th International IEEE EMBS Conference on Neural Engineering, NER 2017 (pp. 469-472). [8008391] (International IEEE/EMBS Conference on Neural Engineering, NER). IEEE Computer Society. https://doi.org/10.1109/NER.2017.8008391
Che, Yanqiu. / Distributed open-loop optogenetic control of cortical epileptiform activity in a Wilson-Cowan network. 8th International IEEE EMBS Conference on Neural Engineering, NER 2017. IEEE Computer Society, 2017. pp. 469-472 (International IEEE/EMBS Conference on Neural Engineering, NER).
@inproceedings{835568b89e0143daac91c763886f7835,
title = "Distributed open-loop optogenetic control of cortical epileptiform activity in a Wilson-Cowan network",
abstract = "This paper presents a distributed open-loop optogenetic control for suppression of epileptiform activity in a neural population model of cortex. In epilepsy, cortical seizures or epileptiform activities occur when pyramidal cells become hyper-excitable due to the loss of inhibitory interneurons. A straightforward way to suppress these epileptiform activities is to inhibit pyramidal cells by exciting interneurons. Thus, in this paper, the inhibitory neural population is targeted for the application of open-loop optogenetic control. By introducing computational model of the light-gated Channelrhodopsin-2 (ChR2) ion channels into the well-known Wilson-Cowan model, we first establish a neural population model for optogenetic control of cortical dynamics. Then, we investigate the effects of open-loop optogenetic control parameters (irradiance intensity and pulse duration) on the control performance. Finally, we use a spatially distributed control strategy to normalize cortical dynamics with minimum optical stimulations. The simulation results demonstrate the effectiveness of our propose control method for suppression of epileptiform activities.",
author = "Yanqiu Che",
year = "2017",
month = "8",
day = "10",
doi = "10.1109/NER.2017.8008391",
language = "English (US)",
series = "International IEEE/EMBS Conference on Neural Engineering, NER",
publisher = "IEEE Computer Society",
pages = "469--472",
booktitle = "8th International IEEE EMBS Conference on Neural Engineering, NER 2017",
address = "United States",

}

Che, Y 2017, Distributed open-loop optogenetic control of cortical epileptiform activity in a Wilson-Cowan network. in 8th International IEEE EMBS Conference on Neural Engineering, NER 2017., 8008391, International IEEE/EMBS Conference on Neural Engineering, NER, IEEE Computer Society, pp. 469-472, 8th International IEEE EMBS Conference on Neural Engineering, NER 2017, Shanghai, China, 5/25/17. https://doi.org/10.1109/NER.2017.8008391

Distributed open-loop optogenetic control of cortical epileptiform activity in a Wilson-Cowan network. / Che, Yanqiu.

8th International IEEE EMBS Conference on Neural Engineering, NER 2017. IEEE Computer Society, 2017. p. 469-472 8008391 (International IEEE/EMBS Conference on Neural Engineering, NER).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Distributed open-loop optogenetic control of cortical epileptiform activity in a Wilson-Cowan network

AU - Che, Yanqiu

PY - 2017/8/10

Y1 - 2017/8/10

N2 - This paper presents a distributed open-loop optogenetic control for suppression of epileptiform activity in a neural population model of cortex. In epilepsy, cortical seizures or epileptiform activities occur when pyramidal cells become hyper-excitable due to the loss of inhibitory interneurons. A straightforward way to suppress these epileptiform activities is to inhibit pyramidal cells by exciting interneurons. Thus, in this paper, the inhibitory neural population is targeted for the application of open-loop optogenetic control. By introducing computational model of the light-gated Channelrhodopsin-2 (ChR2) ion channels into the well-known Wilson-Cowan model, we first establish a neural population model for optogenetic control of cortical dynamics. Then, we investigate the effects of open-loop optogenetic control parameters (irradiance intensity and pulse duration) on the control performance. Finally, we use a spatially distributed control strategy to normalize cortical dynamics with minimum optical stimulations. The simulation results demonstrate the effectiveness of our propose control method for suppression of epileptiform activities.

AB - This paper presents a distributed open-loop optogenetic control for suppression of epileptiform activity in a neural population model of cortex. In epilepsy, cortical seizures or epileptiform activities occur when pyramidal cells become hyper-excitable due to the loss of inhibitory interneurons. A straightforward way to suppress these epileptiform activities is to inhibit pyramidal cells by exciting interneurons. Thus, in this paper, the inhibitory neural population is targeted for the application of open-loop optogenetic control. By introducing computational model of the light-gated Channelrhodopsin-2 (ChR2) ion channels into the well-known Wilson-Cowan model, we first establish a neural population model for optogenetic control of cortical dynamics. Then, we investigate the effects of open-loop optogenetic control parameters (irradiance intensity and pulse duration) on the control performance. Finally, we use a spatially distributed control strategy to normalize cortical dynamics with minimum optical stimulations. The simulation results demonstrate the effectiveness of our propose control method for suppression of epileptiform activities.

UR - http://www.scopus.com/inward/record.url?scp=85028587101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028587101&partnerID=8YFLogxK

U2 - 10.1109/NER.2017.8008391

DO - 10.1109/NER.2017.8008391

M3 - Conference contribution

AN - SCOPUS:85028587101

T3 - International IEEE/EMBS Conference on Neural Engineering, NER

SP - 469

EP - 472

BT - 8th International IEEE EMBS Conference on Neural Engineering, NER 2017

PB - IEEE Computer Society

ER -

Che Y. Distributed open-loop optogenetic control of cortical epileptiform activity in a Wilson-Cowan network. In 8th International IEEE EMBS Conference on Neural Engineering, NER 2017. IEEE Computer Society. 2017. p. 469-472. 8008391. (International IEEE/EMBS Conference on Neural Engineering, NER). https://doi.org/10.1109/NER.2017.8008391