Distribution of enkephalin immunoreactivity in germinative cells of developing rat cerebellum

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Abstract

The cellular distribution of enkephalin, an endogenous opioid, in the developing rat cerebellum was determined by immunocytochemistry. Methionine and leucine enkephalin were concentrated in the external germinal layer, a matrix of proliferative cells; staining was confined to the cortical cytoplasm. Enkephalin was not detected by immunocytochemistry in differentiated neural cells. These results indicate that endogenous opioids are involved specifically in early phases ofnervous system development, particularly cell proliferation and differentiation.

Original languageEnglish (US)
Pages (from-to)1049-1051
Number of pages3
JournalScience
Volume227
Issue number4690
DOIs
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • General

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