Divergence between the Drosophila pseudoobscura and D. persimilis genome sequences in relation to chromosomal inversions

Mohamed A F Noor, David A. Garfield, Stephen Wade Schaeffer, Carlos A. Machado

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

As whole-genome sequence assemblies accumulate, a challenge is to determine how these can be used to address fundamental evolutionary questions, such as inferring the process of speciation. Here, we use the sequence assemblies of Drosophila pseudoobscura and D. persimilis to test hypotheses regarding divergence with gene flow. We observe low differentiation between the two genome sequences in pericentromeric and peritelomeric regions. We interpret this result as primarily a remnant of the correlation between levels of variation and local recombination rate observed within populations. However, we also observe lower differentiation far from the fixed chromosomal inversions distinguishing these species and greater differentiation within and near these inversions. This finding is consistent with models suggesting that chromosomal inversions facilitate species divergence despite interspecies gene flow. We also document heterogeneity among the inverted regions in their degree of differentiation, suggesting temporal differences in the origin of each inverted region consistent with the inversions arising during a process of divergence with gene flow. While this study provides insights into the speciation process using two single-genome sequences, it was informed by lower throughput but more rigorous examinations of polymorphism and divergence. This reliance highlights the need for complementary genomic and population genetic approaches for tackling fundamental evolutionary questions such as speciation.

Original languageEnglish (US)
Pages (from-to)1417-1428
Number of pages12
JournalGenetics
Volume177
Issue number3
DOIs
StatePublished - Nov 1 2007

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Gene Flow
Drosophila
Genome
Population Genetics
Genetic Recombination
Population

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Noor, Mohamed A F ; Garfield, David A. ; Schaeffer, Stephen Wade ; Machado, Carlos A. / Divergence between the Drosophila pseudoobscura and D. persimilis genome sequences in relation to chromosomal inversions. In: Genetics. 2007 ; Vol. 177, No. 3. pp. 1417-1428.
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Divergence between the Drosophila pseudoobscura and D. persimilis genome sequences in relation to chromosomal inversions. / Noor, Mohamed A F; Garfield, David A.; Schaeffer, Stephen Wade; Machado, Carlos A.

In: Genetics, Vol. 177, No. 3, 01.11.2007, p. 1417-1428.

Research output: Contribution to journalArticle

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