Divergence time and population size in the lineage leading to modern humans

Naoyuki Takahata, Yoko Satta, Jan Klein

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

We have developed maximum likelihood (ML) methods for comparisons of nucleotide sequences from unlinked genomic regions. In the case of a single species, the ML method primarily estimates the effective population size (Ne) under both constant size and abrupt expansion conditions. In the case of two or three species, the ML method simultaneously estimates the species divergence time and the effective size of ancestral populations. This allows us to trace the evolutionary history of the human population over the past several million years (my). Available sequences at human autosomal loci indicate Ne= 10,000 in the Late Pleistocene, a figure concordant with the results obtained from mitochondrial DNA sequence and allele-frequency data analysis, and there is no indication of population expansion. The ML analysis of two species shows that humans diverged from chimpanzees 4.6 my ago and that the human and chimpanzee clade diverged from the gorilla 7.2 my ago. Furthermore, the effective population size of humans more than 4.6 my ago is nearly 10 times larger than Neof modern humans. The effective population size in the human lineage does not seem to have remained constant over the past several million pears. The ML model for three species predicts slightly different, but consistent results to those obtained by the two-species analysis.

Original languageEnglish (US)
Pages (from-to)198-221
Number of pages24
JournalTheoretical Population Biology
Volume48
Issue number2
DOIs
StatePublished - Jan 1 1995

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population size
divergence
effective population size
Pan troglodytes
maximum likelihood analysis
nucleotide sequences
probability analysis
Gorilla
human population
mitochondrial DNA
pears
gene frequency
data analysis
genomics
allele
methodology
Pleistocene
history
loci
method

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

Cite this

Takahata, Naoyuki ; Satta, Yoko ; Klein, Jan. / Divergence time and population size in the lineage leading to modern humans. In: Theoretical Population Biology. 1995 ; Vol. 48, No. 2. pp. 198-221.
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Divergence time and population size in the lineage leading to modern humans. / Takahata, Naoyuki; Satta, Yoko; Klein, Jan.

In: Theoretical Population Biology, Vol. 48, No. 2, 01.01.1995, p. 198-221.

Research output: Contribution to journalArticle

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