Diverse roles of non-diverse molecules

MHC class Ib molecules in host defense and control of autoimmunity

Amelia R. Hofstetter, Lucy C. Sullivan, Aron Lukacher, Andrew G. Brooks

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.

Original languageEnglish (US)
Pages (from-to)104-110
Number of pages7
JournalCurrent Opinion in Immunology
Volume23
Issue number1
DOIs
StatePublished - Feb 1 2011

Fingerprint

Autoimmunity
T-Lymphocytes
Histocompatibility Antigens Class I
T-Lymphocyte Subsets
Adaptive Immunity
Innate Immunity
Antigens
Peptides

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Hofstetter, Amelia R. ; Sullivan, Lucy C. ; Lukacher, Aron ; Brooks, Andrew G. / Diverse roles of non-diverse molecules : MHC class Ib molecules in host defense and control of autoimmunity. In: Current Opinion in Immunology. 2011 ; Vol. 23, No. 1. pp. 104-110.
@article{02ab7cae57a0455bb14f6907ea378b80,
title = "Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity",
abstract = "While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.",
author = "Hofstetter, {Amelia R.} and Sullivan, {Lucy C.} and Aron Lukacher and Brooks, {Andrew G.}",
year = "2011",
month = "2",
day = "1",
doi = "10.1016/j.coi.2010.09.009",
language = "English (US)",
volume = "23",
pages = "104--110",
journal = "Current Opinion in Immunology",
issn = "0952-7915",
publisher = "Elsevier Limited",
number = "1",

}

Diverse roles of non-diverse molecules : MHC class Ib molecules in host defense and control of autoimmunity. / Hofstetter, Amelia R.; Sullivan, Lucy C.; Lukacher, Aron; Brooks, Andrew G.

In: Current Opinion in Immunology, Vol. 23, No. 1, 01.02.2011, p. 104-110.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Diverse roles of non-diverse molecules

T2 - MHC class Ib molecules in host defense and control of autoimmunity

AU - Hofstetter, Amelia R.

AU - Sullivan, Lucy C.

AU - Lukacher, Aron

AU - Brooks, Andrew G.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.

AB - While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.

UR - http://www.scopus.com/inward/record.url?scp=79951682868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951682868&partnerID=8YFLogxK

U2 - 10.1016/j.coi.2010.09.009

DO - 10.1016/j.coi.2010.09.009

M3 - Review article

VL - 23

SP - 104

EP - 110

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 1

ER -