Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity

Amelia R. Hofstetter, Lucy C. Sullivan, Aron E. Lukacher, Andrew G. Brooks

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.

Original languageEnglish (US)
Pages (from-to)104-110
Number of pages7
JournalCurrent Opinion in Immunology
Volume23
Issue number1
DOIs
StatePublished - Feb 2011

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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