Abstract
Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.
| Original language | English (US) |
|---|---|
| Article number | 247 |
| Journal | Genome biology |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 9 2015 |
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All Science Journal Classification (ASJC) codes
- Ecology, Evolution, Behavior and Systematics
- Genetics
- Cell Biology
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Diversity of CRISPR-Cas immune systems and molecular machines. / Barrangou, Rodolphe.
In: Genome biology, Vol. 16, No. 1, 247, 09.11.2015.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Diversity of CRISPR-Cas immune systems and molecular machines
AU - Barrangou, Rodolphe
PY - 2015/11/9
Y1 - 2015/11/9
N2 - Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.
AB - Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.
UR - http://www.scopus.com/inward/record.url?scp=84946558100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946558100&partnerID=8YFLogxK
U2 - 10.1186/s13059-015-0816-9
DO - 10.1186/s13059-015-0816-9
M3 - Review article
C2 - 26549499
AN - SCOPUS:84946558100
VL - 16
JO - Genome Biology
JF - Genome Biology
SN - 1474-7596
IS - 1
M1 - 247
ER -