Diversity of CRISPR-Cas immune systems and molecular machines

Rodolphe Barrangou

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.

Original languageEnglish (US)
Article number247
JournalGenome biology
Volume16
Issue number1
DOIs
StatePublished - Nov 9 2015

Fingerprint

CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats
nucleases
Adaptive Immunity
nucleic acid
immune system
immunity
Nucleic Acids
nucleic acids
targeting
RNA
Immune System
genome
Genome
DNA
adaptive immunity

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Cite this

Barrangou, Rodolphe. / Diversity of CRISPR-Cas immune systems and molecular machines. In: Genome biology. 2015 ; Vol. 16, No. 1.
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Diversity of CRISPR-Cas immune systems and molecular machines. / Barrangou, Rodolphe.

In: Genome biology, Vol. 16, No. 1, 247, 09.11.2015.

Research output: Contribution to journalReview article

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AU - Barrangou, Rodolphe

PY - 2015/11/9

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