Diverticular disease is associated with benign intra-abdominal cystic disease

Paula F. Wrafter, Tara M. Connelly, Jody S.A. Khan, Brian C. Lucey, Arthur Berg, Walter Koltun, William P. Joyce

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Diverticular disease (DD) and hepatic and renal cysts have been linked with defects in collagen and dysfunctional matrix metalloproteinases. Methods: Consecutive abdominal computed tomography scans between January-July 2015 were prospectively studied to determine a correlation between visceral cysts and DD. Patients with a sigmoid colectomy for pathology other than DD and scans in which DD and/or solid organs were not fully visualized were excluded. A subgroup analysis was performed on youthful DD patients (<55 years of age, n = 32) vs. older controls (>55, n = 213). Results: 238 DD patients (50.8% male) and 369 controls (40.5% male, p =.02) were included. Incidence of visceral cystic disease in DD patients vs. controls was 71.4% vs. 22.5% (p < 0.00001). Renal cysts, present in 53.4% of the DD patients and 18.7% of the controls (p <.00001), were more common than hepatic cysts in both groups. Hepatic cyst prevalence was 8.8 vs. 2.4% (p =.0008). In the subgroup analysis, cystic disease was present in 56.2% of youthful DD patients vs. 29.1% of older controls (p =.004). Conclusions: A significant association between cystic disease and DD was demonstrated overall and in subgroup analysis inclusive of youthful DD patients and older controls. These findings suggest a global defect in connective tissue integrity in DD patients.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalExpert Review of Gastroenterology and Hepatology
Volume11
Issue number5
DOIs
StatePublished - May 4 2017

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Cysts
Liver
Kidney
Colectomy
Sigmoid Colon
Matrix Metalloproteinases
Connective Tissue
Collagen
Tomography
Pathology
Incidence

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Wrafter, Paula F. ; Connelly, Tara M. ; Khan, Jody S.A. ; Lucey, Brian C. ; Berg, Arthur ; Koltun, Walter ; Joyce, William P. / Diverticular disease is associated with benign intra-abdominal cystic disease. In: Expert Review of Gastroenterology and Hepatology. 2017 ; Vol. 11, No. 5. pp. 487-490.
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abstract = "Background: Diverticular disease (DD) and hepatic and renal cysts have been linked with defects in collagen and dysfunctional matrix metalloproteinases. Methods: Consecutive abdominal computed tomography scans between January-July 2015 were prospectively studied to determine a correlation between visceral cysts and DD. Patients with a sigmoid colectomy for pathology other than DD and scans in which DD and/or solid organs were not fully visualized were excluded. A subgroup analysis was performed on youthful DD patients (<55 years of age, n = 32) vs. older controls (>55, n = 213). Results: 238 DD patients (50.8{\%} male) and 369 controls (40.5{\%} male, p =.02) were included. Incidence of visceral cystic disease in DD patients vs. controls was 71.4{\%} vs. 22.5{\%} (p < 0.00001). Renal cysts, present in 53.4{\%} of the DD patients and 18.7{\%} of the controls (p <.00001), were more common than hepatic cysts in both groups. Hepatic cyst prevalence was 8.8 vs. 2.4{\%} (p =.0008). In the subgroup analysis, cystic disease was present in 56.2{\%} of youthful DD patients vs. 29.1{\%} of older controls (p =.004). Conclusions: A significant association between cystic disease and DD was demonstrated overall and in subgroup analysis inclusive of youthful DD patients and older controls. These findings suggest a global defect in connective tissue integrity in DD patients.",
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Diverticular disease is associated with benign intra-abdominal cystic disease. / Wrafter, Paula F.; Connelly, Tara M.; Khan, Jody S.A.; Lucey, Brian C.; Berg, Arthur; Koltun, Walter; Joyce, William P.

In: Expert Review of Gastroenterology and Hepatology, Vol. 11, No. 5, 04.05.2017, p. 487-490.

Research output: Contribution to journalArticle

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T1 - Diverticular disease is associated with benign intra-abdominal cystic disease

AU - Wrafter, Paula F.

AU - Connelly, Tara M.

AU - Khan, Jody S.A.

AU - Lucey, Brian C.

AU - Berg, Arthur

AU - Koltun, Walter

AU - Joyce, William P.

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N2 - Background: Diverticular disease (DD) and hepatic and renal cysts have been linked with defects in collagen and dysfunctional matrix metalloproteinases. Methods: Consecutive abdominal computed tomography scans between January-July 2015 were prospectively studied to determine a correlation between visceral cysts and DD. Patients with a sigmoid colectomy for pathology other than DD and scans in which DD and/or solid organs were not fully visualized were excluded. A subgroup analysis was performed on youthful DD patients (<55 years of age, n = 32) vs. older controls (>55, n = 213). Results: 238 DD patients (50.8% male) and 369 controls (40.5% male, p =.02) were included. Incidence of visceral cystic disease in DD patients vs. controls was 71.4% vs. 22.5% (p < 0.00001). Renal cysts, present in 53.4% of the DD patients and 18.7% of the controls (p <.00001), were more common than hepatic cysts in both groups. Hepatic cyst prevalence was 8.8 vs. 2.4% (p =.0008). In the subgroup analysis, cystic disease was present in 56.2% of youthful DD patients vs. 29.1% of older controls (p =.004). Conclusions: A significant association between cystic disease and DD was demonstrated overall and in subgroup analysis inclusive of youthful DD patients and older controls. These findings suggest a global defect in connective tissue integrity in DD patients.

AB - Background: Diverticular disease (DD) and hepatic and renal cysts have been linked with defects in collagen and dysfunctional matrix metalloproteinases. Methods: Consecutive abdominal computed tomography scans between January-July 2015 were prospectively studied to determine a correlation between visceral cysts and DD. Patients with a sigmoid colectomy for pathology other than DD and scans in which DD and/or solid organs were not fully visualized were excluded. A subgroup analysis was performed on youthful DD patients (<55 years of age, n = 32) vs. older controls (>55, n = 213). Results: 238 DD patients (50.8% male) and 369 controls (40.5% male, p =.02) were included. Incidence of visceral cystic disease in DD patients vs. controls was 71.4% vs. 22.5% (p < 0.00001). Renal cysts, present in 53.4% of the DD patients and 18.7% of the controls (p <.00001), were more common than hepatic cysts in both groups. Hepatic cyst prevalence was 8.8 vs. 2.4% (p =.0008). In the subgroup analysis, cystic disease was present in 56.2% of youthful DD patients vs. 29.1% of older controls (p =.004). Conclusions: A significant association between cystic disease and DD was demonstrated overall and in subgroup analysis inclusive of youthful DD patients and older controls. These findings suggest a global defect in connective tissue integrity in DD patients.

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