DNA biosensor by using magnetic nanomaterials and serial signal amplification strategy

Xu Yu, Si Yang Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It is important to develop highly sensitive and selective biosensors for detection of specific DNA sequences due to the low abundance of disease specific DNA and the complexity of the biological samples in the clinical trials. To meet this challenge, the signal amplification strategy based on hybridization chain reaction (HCR) is particular attractive because it doesn't need enzyme or labeling process [1]. Recently, a signal amplification approach with enzyme-induced silver metallization on the gold nanoparticles (AuNPs) for sensitive colorimetric detection of avian influenza viruses was reported [2]. Herein, we propose a highly sensitive and selective biosensor that combines HCR signal amplification with enzyme-induced metallization for colorimetric sequence-specific DNA detection.

Original languageEnglish (US)
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1671-1673
Number of pages3
ISBN (Electronic)9780979806483
StatePublished - Jan 1 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

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All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Yu, X., & Zheng, S. Y. (2015). DNA biosensor by using magnetic nanomaterials and serial signal amplification strategy. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1671-1673). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.